Nos publications

Is Compritol® 888 ATO chemically stable in hot melt extrusion process at high temperature?

  • Poster

AAPS Annual Meeting and Exposition – San Diego (USA)  - nov 2014

Yvonne Rosiaux, Jean-Michel Girard, Florence Desvignes, Cédric Miolane, Delphine Marchaud

Solid lipid excipients: born to be extruded!

  • Whitepaper

nov 2014

Gattefossé

Functional excipients are critical to the successful application of HME to resolve formulation challenges. Whilst polymers show potential in both controlled release and in improving the solubility and dissolution of poorly soluble compounds they are not ideal materials for extrusion. Lipid excipients are distinctly different to polymers and behave differently in HME. This article highlights two glyceride-esters: Compritol® 888 ATO and Precirol® ATO 5. They melt at relatively low temperatures and recrystallize quickly. They extrude well and can produce strand-like extrudates which can be down streamed into powders or granules. 

 

These glyceride-esters can be used as release retarding agents/dissolution modifiers for both insoluble and soluble drugs even for high drug loading. In combination with plastic polymers they also can act as plasticizer/processing aid enabling lower temperature process and continuous production. 

 

At Gattefossé we aim to share our knowledge to help formulators use lipid excipients to their best advantage. 

Effect of Tablet Structure on Controlled Release from Supersaturating Solid Dispersions Containing Glyceryl Behenate.

  • Scientific publication

Mol. Pharmaceutics, 2015, 12 (1), pp 120–126 DOI: 10.1021/mp500480y - oct 2014

Justin M. Keen, Justin R. Hughey, Ryan C. Bennett, Vincent Jannin, Yvonne Rosiaux, Delphine Marchaud, and James W. McGinity

Estimating in vivo drug release from a new theophylline Compritol® 888 ATO matrix formulation using appropriate biorelevant test methods

  • Poster

CRS Annual Meeting – Chicago (USA)  - jui 2014

N. Fotaki, C. M. Long, Y. Rosiaux, D. Marchaud, Grzegorz Garbacz, S. Lange and S. Klein

Streamlining the design of sustained release matrix tablets using mathematical modeling for drug release optimization

  • Poster

CRS Annual Meeting – Chicago (USA)  - jui 2014

Y. Rosiaux, F. Desvignes, JM. Girard, C. Miolane, S. Hughes and D. Marchaud

Colour coating of Compritol® 888 ATO matrix tablets: a feasability study

  • Poster

AAPS Annual Meeting and Exposition – San Diego (USA)  - 2014

Yvonne Rosiaux, Susanne Muschert, Delphine Marchaud

Smart strategies for sustained release matrix tablets: Compritol® 888 ATO

  • Whitepaper

OutsourcingPharma - mai 2014

Gattefossé

This white paper gives an overview of how Compritol® 888 ATO provides clinically relevant sustained drug release profiles along with biopharmaceutical, formulation and manufacturing advantages.

Hot melt extrusion with Compritol® 888 ATO: determination of processing boundaries

  • Poster

PBP World Meeting – Vienna (Austria)  - mar 2014

Yvonne Cuppok-Rosiaux, Florence Desvignes, Jean-Michel Girard, Cédric Miolane, Delphine Marchaud

Percolation threshold of Compritol® 888 in matrix tablets: assessing the minimum concentration to create an infinite lipid network

  • Poster

AAPS Annual Meeting and Exposition – San Antonio (USA)  - nov 2013

Y. CUPPOK-ROSIAUX, J-M. GIRARD, F. DESVIGNES, C. MIOLANE, D. MARCHAUD