Nos publications
Is Compritol® 888 ATO chemically stable in hot melt extrusion process at high temperature?
AAPS Annual Meeting and Exposition – San Diego (USA) - nov 2014
Solid lipid excipients: born to be extruded!
nov 2014
Functional excipients are critical to the successful application of HME to resolve formulation challenges. Whilst polymers show potential in both controlled release and in improving the solubility and dissolution of poorly soluble compounds they are not ideal materials for extrusion. Lipid excipients are distinctly different to polymers and behave differently in HME. This article highlights two glyceride-esters: Compritol® 888 ATO and Precirol® ATO 5. They melt at relatively low temperatures and recrystallize quickly. They extrude well and can produce strand-like extrudates which can be down streamed into powders or granules.
These glyceride-esters can be used as release retarding agents/dissolution modifiers for both insoluble and soluble drugs even for high drug loading. In combination with plastic polymers they also can act as plasticizer/processing aid enabling lower temperature process and continuous production.
At Gattefossé we aim to share our knowledge to help formulators use lipid excipients to their best advantage.
Effect of Tablet Structure on Controlled Release from Supersaturating Solid Dispersions Containing Glyceryl Behenate.
Mol. Pharmaceutics, 2015, 12 (1), pp 120–126 DOI: 10.1021/mp500480y - oct 2014
Estimating in vivo drug release from a new theophylline Compritol® 888 ATO matrix formulation using appropriate biorelevant test methods
CRS Annual Meeting – Chicago (USA) - jui 2014
Streamlining the design of sustained release matrix tablets using mathematical modeling for drug release optimization
CRS Annual Meeting – Chicago (USA) - jui 2014
Colour coating of Compritol® 888 ATO matrix tablets: a feasability study
AAPS Annual Meeting and Exposition – San Diego (USA) - 2014
Smart strategies for sustained release matrix tablets: Compritol® 888 ATO
OutsourcingPharma - mai 2014
This white paper gives an overview of how Compritol® 888 ATO provides clinically relevant sustained drug release profiles along with biopharmaceutical, formulation and manufacturing advantages.
Hot melt extrusion with Compritol® 888 ATO: determination of processing boundaries
PBP World Meeting – Vienna (Austria) - mar 2014
Percolation threshold of Compritol® 888 in matrix tablets: assessing the minimum concentration to create an infinite lipid network
AAPS Annual Meeting and Exposition – San Antonio (USA) - nov 2013