Nos publications
Influence of Formulation Factors and Compression Force on Release Profile of Sustained Release Metoprolol Tablets using Compritol® 888 ATO as Lipid Excipient
Indian J Pharm Sci 2015;77(5): 620-625 - sep 2015
Release profile of metoprolol from sustained release tablets using Compritol® 888 ATO as SR lipid matrix agent showed high reliability. Different sources of active ingredient and batches of Compritol® were evaluated at different compression forces and in dissolution media containing or not ethanol. The formulation appeared to be very robust and is not affected by these variables. Therefore Compritol® offers great potential in the formulation of reliable SR tablets.
New insights into the stability of SR lipid matrix tablets
CRS Annual Meeting – Edinburgh (Scotland) - jui 2015
Optimizing a wet granulation process to obtain high-dose sustained-release tablets with Compritol® 888 ATO.
Drug Development and Industrial Pharmacy, Volume 41 - Issue 10 https://doi.org/10.3109/03639045.2014.1002410 - fév 2015
This study demonstrates how a wet granulation with Compritol® 888 is an effective approach to improve material flow and compressibility. High-dose lipid matrix tablets with sustained release profiles were successfully produced.
Exploring the possible relationship between the drug release of Compritol®-containing tablets and its polymorph forms using micro X-ray diffraction
Journal of Controlled Release, Volume 197, Pages 158-164 https://doi.org/10.1016/j.jconrel.2014.11.013 - jan 2015