Nos publications

Toward improving the in vitro in vivo correlation of lipid-based formulations using a simplified gastro-intestinal lipolysis protocol

  • Poster

AAPS - oct 2024

Elise Dauphin-Chanard, Stéphanie Chevrier, Malaury Ducros, Philippe Caisse

Lipid-based formulations (LBF) enhance the oral bioavailability of poorly water-soluble drugs by maintaining them in a solubilized state during digestion. This study aims to establish a robust protocol to evaluate the impact of gastro-intestinal lipolysis on LBF performance, using cinnarizine as a model drug.

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GELUCIRE® 4414 for type IV lipid based formulations and their in vitro in vivo performance evaluation

  • Poster

AAPS PharmSci360 – Philadelphia (USA)  - 2021

In this study, Gelucire® 44/14 in type IV lipid-based formulation has been evaluated to increase the solubility and in vivo performance of ticagrelor. 

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A Novel Approach To Prepare Solid Self-microemulsifying Drug Delivery System Without A Solid-phase Carrier Using 3D Printing

  • Poster

CRS Annual Meeting – New York (USA)  - jui 2018

KapilkumarVithani, Alvaro Goyanes, Vincent Jannin, Simon Gaisford, Ben Boyd

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The Gelucire® family

  • Whitepaper

Pharma Excipients  - 2018

Gattefossé

Size characterization of lipid-based self-emulsifying pharmaceutical excipients during lipolysis using Taylor dispersion analysis with fluorescence detection

  • Scientific publication

International Journal of Pharmaceutics, Volume 537, Issues 1–2, Pages 94–101 - fév 2018

Joseph Chamieh, Habib Merdassi, Jean-Christophe Rossi, Vincent Jannin, Frédéric Demarne, Hervé Cottet

In this work, the lipolysis of Labrasol® and Gelucire® 44/14 , two lipid based self-emulsifying drug delivery systems, by pancreatic enzymes and under conditions mimicking the gastrointestinal tract is followed by Taylor dispersion analysis. Results show that, Labrasol® droplets decrease exponentially in size with lipolysis time, whereas Gelucire® 44/14 droplets increased sigmoïdally in size. Even after 120 min lipolysis, both systems maintain a solubilizing capacity of the hydrophobic marker.

Macrogol esters: Influence on in vitro and in vivo dissolution of a poorly soluble drug

  • Poster

AAPS Annual Meeting & Exposition – San Diego (USA)  - nov 2017

Chhanda Kapadia, Meenakshi Venkataraman, Megha Marwah , Nabil J Farah , M.S. Nagarsenker

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In-vitro investigation regarding the effects of Gelucire® 44/14 and Labrasol® ALF on the secretory intestinal transport of P-gp substrates

  • Scientific publication

International Journal of Pharmaceutics, Volume 515, Issues 1–2, Pages 293-299 https://doi.org/10.1016/j.ijpharm.2016.10.012 - déc 2016

Océane Dubray, Vincent Jannin, Fréderic Demarne, Yann Pellequer, Alf Lamprecht, Arnaud Béduneau

Formulation of a self-emulsifying lipid formulation of curcumin

  • Poster

AAPS Annual Meeting & Exposition – San Diego (USA)  - 2014

Vincent Jannin, Camille Dumont, Hamza Benhaddou, Stéphanie Chevrier, Yann Chavant, Christophe Voutsinas, Frédéric Demarne

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Establishment of a binary phase diagrams database for the development of self-emulsifying lipid-based formulations

  • Poster

AAPS Annual Meeting and Exposition – San Diego (USA)  - 2014

Jannin, Vincent; Benhaddou, Hamza; Dumont, Camille; Chevrier, Stéphanie; Chavant, Yann; Demarne, Frédéric