Nos publications
Implementation of an at-line nanoparticle size analyzer in a continuous nano-manufacturing line considering critical measurement and process conditions
PBP - mar 2024
Nanopharmaceuticals' size is a critical quality attribute. This work provides insights about the implementation of an at-line particle size analyzer in a continuous manufacturing line of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC).
Establishment of a continuous inline-monitored nano-production line using the Microfluidizer® technology for the fabrication of safe lipid-based nanoparticles
Macedonian Pharmaceutical Bulletin - sep 2023
Nano-drug delivery systems (NDDS) serve as a promising platform in modern medicine, facilitating the targeted delivery of drugs due to their versatile size, structure, and composition. However, the current industrial production of NDDS relies on cumbersome batch processes that are costly, difficult to scale, and lack adequate control. This study focuses on enhancing industrial-scale production through the development and testing of a continuous top-down production line, utilizing scalable Microfluidizer® technology for solvent-free preparation of lipid-based nanoparticles.
In Vitro Studies Indicate Promising Properties Of Solid Lipid Nanosuspensions for oral peptide delivery
CRS Annual Meeting – Valencia (Spain) - jui 2019
High shear blending with glyceryl distearate provides individually coated drug particles for effective taste masking
Journal of Drug Delivery Science and Technology, Volume 48, Pages 437-449 - déc 2018
In this study the authors used:
– A design of experiment, to evaluate the effect of process parameters (blending speed, chopper speed and coating time) on drug particle size.
– Potassium chloride as model drug.
The study showed:
– Individual particle coating was achieved at 450 rpm with 20% glyceryl distearate (Precirol® ATO 5) at 48°C
– High shear coating is as efficient as fluid bed coating for taste masking
– A trained sensory panel confirmed the effectiveness of the process on taste masking
High shear coating: a versatile taste-masking process
ONdrugDelivery Magazine, Issue 88, pages 10-13 - jui 2018
Copyright © 2018 Frederick Furness Publishing Ltd
Taste-masked drugs for pediatric medicines through lipid coating
AAPS Annual Meeting & Exposition – San Diego (USA) - nov 2017
Efficient taste masking through high shear coating
9th Conference of the European Paediatric Formulation Initiative - 2017
Solid lipid excipients: born to be extruded!
nov 2014
Functional excipients are critical to the successful application of HME to resolve formulation challenges. Whilst polymers show potential in both controlled release and in improving the solubility and dissolution of poorly soluble compounds they are not ideal materials for extrusion. Lipid excipients are distinctly different to polymers and behave differently in HME. This article highlights two glyceride-esters: Compritol® 888 ATO and Precirol® ATO 5. They melt at relatively low temperatures and recrystallize quickly. They extrude well and can produce strand-like extrudates which can be down streamed into powders or granules.
These glyceride-esters can be used as release retarding agents/dissolution modifiers for both insoluble and soluble drugs even for high drug loading. In combination with plastic polymers they also can act as plasticizer/processing aid enabling lower temperature process and continuous production.
At Gattefossé we aim to share our knowledge to help formulators use lipid excipients to their best advantage.
Compritol® 888 ATO vs Precirol® ATO 5 in hot melt extrusion: investigation of operating window limits
AAPS Annual Meeting and Exposition – San Diego (USA) - nov 2014