Nos publications
Effect of Select Enhancers on the Permeation of Caffeine Across Strat® M Membrane
CRS Annual Meeting – Montreal (Canada) - jui 2022
Importance of standardizing protocols for pig skin preparation to ensure reliable in vitro permeation test (IVPT) results
CRS Annual Meeting – Montreal (Canada) - jui 2022
Critical Criteria for Assessing the Permeation Performance of Topical Formulas on Animal Skin: Standardization of IVPT Protocols
PBP World Meeting – Rotterdam (The Netherlands) - mar 2022
To assess the performance of dermal/transdermal formulation, in vitro permeation test (IVPT) with Franz cells is a reliable, reproducible, and widely used technique1. Due to its histological similarity, pig skin is a common model used as an alternative to human skin2. However, careful consideration should be given to the pig skin preparation, as both permeability and lag time can be greatly affected. The main variation sources are pig skin storage time, skin integrity and thickness, sample quantity and methodology to apply the formulation on the membrane. This study aims to investigate the critical parameters affecting the data’s accuracy by evaluating the permeation of a lidocaine hydrochloride-based gel (LID HCl) on pig skin.