Nos publications

Effect of Select Enhancers on the Permeation of Caffeine Across Strat® M Membrane

  • Poster

CRS Annual Meeting – Montreal (Canada)  - jui 2022

Masumi Dave ; Jasmine Musakhanian ; Jason LePree and Rollie Fuller

Importance of standardizing protocols for pig skin preparation to ensure reliable in vitro permeation test (IVPT) results

  • Poster

CRS Annual Meeting – Montreal (Canada)  - jui 2022

E. Dauphin-Chanard; A. Forest; C. Deleglise; D. Hoste; P. Caisse

Critical Criteria for Assessing the Permeation Performance of Topical Formulas on Animal Skin: Standardization of IVPT Protocols

  • Poster

PBP World Meeting – Rotterdam (The Netherlands)  - mar 2022

E. Dauphin-Chanard; A. Forest; C. Deleglise; D. Hoste; P. Caisse

To assess the performance of dermal/transdermal formulation, in vitro permeation test (IVPT) with Franz cells is a reliable, reproducible, and widely used technique1. Due to its histological similarity, pig skin is a common model used as an alternative to human skin2. However, careful consideration should be given to the pig skin preparation, as both permeability and lag time can be greatly affected. The main variation sources are pig skin storage time, skin integrity and thickness, sample quantity and methodology to apply the formulation on the membrane. This study aims to investigate the critical parameters affecting the data’s accuracy by evaluating the permeation of a lidocaine hydrochloride-based gel (LID HCl) on pig skin.