Nos publications

Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione

  • Scientific publication

International Journal of Pharmaceutics, Volume 523, Issue 1, Pages 357–365 https://doi.org/10.1016/j.ijpharm.2017.03.027 - mai 2017

Gergely Hetényi, Janine Griesser, Michael Moser, Frédéric Demarne, Vincent Jannin, Andreas Bernkop-Schnürch.

This study shows that independent from the type of peptide all the SEDDS showed a prolonged release and can provide a 100% protective effect towards protease degradation and deactivation by reduced glutathione.

Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery systems

  • Scientific publication

International Journal of Pharmaceutics, Volume 520, Issues 1–2, 30 March 2017, Pages 267–274 - mar 2017

Janine Griesser, Gergely Hetényi, Michael Moser, Frédéric Demarne, Vincent Jannin, Andreas Bernkop-Schnürch.

In this study, hydrophobic ion pairing is used to form complexes between different anionic surfactants and leuprorelin, insulin and desmopression as model peptides. These complexes were formulated in SEDDS and evaluated for payload and stability.