Nos publications
Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione
International Journal of Pharmaceutics, Volume 523, Issue 1, Pages 357–365 https://doi.org/10.1016/j.ijpharm.2017.03.027 - mai 2017
This study shows that independent from the type of peptide all the SEDDS showed a prolonged release and can provide a 100% protective effect towards protease degradation and deactivation by reduced glutathione.
Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery systems
International Journal of Pharmaceutics, Volume 520, Issues 1–2, 30 March 2017, Pages 267–274 - mar 2017
In this study, hydrophobic ion pairing is used to form complexes between different anionic surfactants and leuprorelin, insulin and desmopression as model peptides. These complexes were formulated in SEDDS and evaluated for payload and stability.