Nos publications

Gelucire® 48/16: a solid surfactant for tablets

  • Whitepaper

Pharma Times, Vol. 48 – N° 11 – pp 17-22  - nov 2016

Ketkee Deshmukh and Chhanda Kapadia

This article describes Gelucire® 48/16 – a novel pegylated lipid excipient, and its use as a solid surfactant for solubility enhancement. 

Impact of hot and wet granulation techniques on Compritol® 888 ATO lipid matrices for extended release of highly water soluble high dose API

  • Poster

CRS Annual Meeting – Seattle (2016)  - 2016

Ketkee Deshmukh, Chhanda Kapadia, Agnivesh Shrivastava, Gayatri Khanvilkar, Pradnya Vaingankar and Purnima Amin

The poster describes the formulation of sustained release tablets with Metformin HCl (a well-known oral antihyperglycemic) using Compritol® 888 ATO as a sustained release agent. Different granulation techniques were evaluated to elucidate the impact of formulation and process on tablet properties and drug release. The objective was to determine a simple process that enables the production of ‘smaller’ tablets, using less excipients, whilst maintaining therapeutic drug dose and obtaining drug release which passes Pharmacopeial specifications.