Nos publications

Understanding Microemulsions and Nanoemulsions in (Trans)Dermal Delivery

  • Scientific publication

AAPS PharmSciTech - jan 2025

Jasmine Musakhanian, David W. Osborne

Microemulsions and nanoemulsions are explored in pharmaceuticals for their potential in delivering clinically relevant drug doses across biological membranes. Despite extensive literature, there's a lack of clear distinctions between the two in terms of definitions and mechanisms: this review aims to uncover less obvious yet important mechanisms in transdermal drug delivery.

Unveiling the Potential of Labrasol® ALF Labrafac™ MC60 and Capryol® 90 as Permeation Enhancers to Address Low Bioavailability Issues

  • Whitepaper

American Pharmaceutical Review - oct 2024

Cécile Morin, Philippe Caisse

In vitro, ex vivo, and in vivo tests show that Labrasol® ALF, Labrafac™ MC60, and Capryol® 90 are effective and safe permeation enhancers. They work by temporarily opening tight junctions in the intestinal lining, potentially improving the bioavailability of poorly permeable drugs, including small molecules (BCS III and IV) and large molecules like peptides and proteins.

Synergising excipients to boost skin delivery

  • Whitepaper

ONdrugDelivery Magazine, Issue 99, pp 54-58. - aou 2019

C. Morin and D. Marchaud

This article focuses on Transcutol® P, Capryol® and Lauroglycol™ as their synergism brings eye-opening benefits in topical formulations.

In Vitro Studies Indicate Promising Properties Of Solid Lipid Nanosuspensions for oral peptide delivery

  • Poster

CRS Annual Meeting – Valencia (Spain)  - jui 2019

Camille Dumont, Ana Beloqui, Sandrine Bourgeois, Véronique Préat, Hatem Fessi, Vincent Jannin

Télécharger (.pdf - 1.51 Mo)

Establishment of a binary phase diagrams database for the development of self-emulsifying lipid-based formulations

  • Poster

AAPS Annual Meeting and Exposition – San Diego (USA)  - 2014

Jannin, Vincent; Benhaddou, Hamza; Dumont, Camille; Chevrier, Stéphanie; Chavant, Yann; Demarne, Frédéric

Self-formulation protocol: Part II: excipient selection, diagram design and selection of prototype formulations.

  • Poster

AAPS Annual Meeting and Exposition - San Antonio (USA)  - nov 2013

Jannin, Vincent; Michenaud, Mathieu; Belotti, S.; André, C.; Chevrier, Stéphanie; Chavant, Yann et al. (2013)

Dispersion test and ternary diagramming are detailed, to determine the excipient ratios and prototype formulations 

Télécharger (.pdf - 785.65 Ko)

Self-formulation protocol: Part III: impact of lipolysis on prototype formulations

  • Poster

AAPS Annual Meeting and Exposition - San Antonio (USA)  - 2013

Jannin, Vincent; Michenaud, Mathieu; Belotti, S.; André, C.; Chevrier, Stéphanie; Chavant, Yann et al. (2013)

Lipolysis test is used to determine the capacity of prototype formulations to maintain drug in solubilized state. 

Télécharger (.pdf - 1.46 Mo)

Self-formulation protocol: Part I: Solubility determination in liquid and solid excipients

  • Poster

AAPS Annual Meeting and Exposition – San Antonio (USA)  - 2013

Jannin, Vincent; Michenaud, Mathieu; Belotti, S.; André, C.; Chevrier, Stéphanie; Chavant, Yann et al.

Dispersion test and ternary diagramming are detailed, to determine the excipient ratios and prototype formulations 

Télécharger (.pdf - 400.94 Ko)