Nos publications
Understanding Microemulsions and Nanoemulsions in (Trans)Dermal Delivery
AAPS PharmSciTech - jan 2025
Microemulsions and nanoemulsions are explored in pharmaceuticals for their potential in delivering clinically relevant drug doses across biological membranes. Despite extensive literature, there's a lack of clear distinctions between the two in terms of definitions and mechanisms: this review aims to uncover less obvious yet important mechanisms in transdermal drug delivery.
Skin Penetration and Permeation Properties of Transcutol® in Complex Formulations
AAPS PharmSciTech - sep 2024
The review examines how hydroalcoholic solvents, especially Transcutol, enhance drug delivery in multi-component formulations. It highlights factors like drug diffusion, solubilization, and skin absorption, focusing on the interaction between drug properties, skin barrier, and formulation for effective (trans)dermal delivery.
Rheology as a tool for characterizing topical product formulations: impact of solubilizer variation on stability and structure
CRS - jui 2024
The use of solubilizers in a topical formulation helps solubilization of poorly soluble APIs. Therefore, it is essential to have a formulation chassis that can be modulated to incorporate this quantity of solubilizer. In this poster, the influence of different excipients as solubilizers and their variation on the stability and rheological properties of topical creams is investigated.
Formulating pharmaceutical topical dosage forms with high level of solvents and minimal quantity of water
PBP - mar 2024
This poster dives into the formulation of topical dosage forms containing the maximum amount of solvent and the minimum amount of water, while ensuring their stability upon storage.
Synergising excipients to boost skin delivery
ONdrugDelivery Magazine, Issue 99, pp 54-58. - aou 2019
This article focuses on Transcutol® P, Capryol® and Lauroglycol™ as their synergism brings eye-opening benefits in topical formulations.
Skin Penetration and Permeation Properties of Transcutol®—Neat or Diluted Mixtures
AAPS PharmSciTech, Vol. 19, No.8 DOI: 10.1208/s12249-018-1196-8 - nov 2018
In this critical article, the authors have reviewed numerous studies in order to elucidate the mechanism of action of the highly purified diethylene glycol monoethyl ether TRANSCUTOL® on skin penetration and permeation.
Development of a daphnetin transdermal patch using chemical enhancer strategy: insights of the enhancement effect of Transcutol P and the assessment of pharmacodynamics.
Drug Dev Ind Pharm. 2018 Oct;44(10):1642-1649. doi: 10.1080/03639045.2018.1483391. Epub 2018 Jul 2. - jui 2018
A patch for transdermal delivery of daphnetin was developed using Transcutol® P as permeation enhancer.
The study showed:
10% Transcutol® P led to a significant increase in drug release from the patch.
Patch exhibited analgesic and anti-inflammatory activity
Efficient skin delivery: no compromise with Transcutol®
OutsourcingPharma - nov 2015
This white paper describes Transcutol®, the highest purified pharmaceutical grade of Diethylene Glyceryl monoEthylEther (DEGEE).
Scientific publications asserting the safety of Transcutol® are listed to highlight the non-skin irritant property of Transcutol®. Moreover, solvent properties of Transcutol® are described and solubility data in different solvents are given to illustrate the remarkable solvent capacity of Transcutol®.
This exceptional safety and solvent property make Transcutol® an ideal chemical penetration enhancer for topical formulations, where efficiency and non skin irritancy are key success factors. Examples of commercial uses of DEGEE are cited to illustrate the versatility of use of this excipient in many different topical dosage forms. Practical information is also given for the formulation of Transcutol® in many topical dosage forms.
