Nos publications

Biorelevant media resistant co-culture model mimicking permeability of human intestine.

• Scientific publication

International Journal of Pharmaceutics, Volume 481, Issues 1–2, Pages 27-36 - mar 2015

Delphine Antoine, Yann Pellequer, Camille Tempesta, Stefan Lorscheidt, Bernadette Kettel, Lana Tamaddon, Vincent Jannin, Frédéric Demarne, Alf Lamprecht, Arnaud Béduneau

Cell culture models are currently used to predict absorption pattern of new compounds and formulations in the human gastro-intestinal tract (GIT). One major drawback is the lack of relevant apical incubation fluids allowing mimicking luminal conditions in the GIT. Here, we suggest a culture model compatible with biorelevant media, namely Fasted State Simulated Intestinal Fluid (FaSSIF) and Fed State Simulated Intestinal Fluid (FeSSIF).

A tunable Caco-2/HT29-MTX co-culture model mimicking variable permeabilities of the human intestine obtained by an original seeding procedure

• Scientific publication

European Journal of Pharmaceutics and Biopharmaceutics, Volume 87, Issue 2, Pages 290-298 https://doi.org/10.1016/j.ejpb.2014.03.017 - jui 2014

Arnaud Béduneau, Camille Tempesta, Stéphane Fimbel, Yann Pellequer, Vincent Jannin, Frédéric Demarne , Alf Lamprecht

Influence of intestinal biorelevant fluids on a novel co-culture cell model able to mimic varaible permeabilities of the human intestine

• Poster

AAPS Annual Meeting and Exposition – San Antonio (USA)  - 2013

C. TEMPESTA, A. BÉDUNEAU, V. JANNIN, Y. PELLEQUER, F. DEMARNE, A. LAMPRECHT