Nos publications
Designing aqueous gels with lipophilic solubilizers for dermal application
AAPS Annual Meeting and Exposition – San Diego (USA) - nov 2014
Compritol® 888 ATO vs Precirol® ATO 5 in hot melt extrusion: investigation of operating window limits
AAPS Annual Meeting and Exposition – San Diego (USA) - nov 2014
Solid lipid excipients: born to be extruded!
nov 2014
Functional excipients are critical to the successful application of HME to resolve formulation challenges. Whilst polymers show potential in both controlled release and in improving the solubility and dissolution of poorly soluble compounds they are not ideal materials for extrusion. Lipid excipients are distinctly different to polymers and behave differently in HME. This article highlights two glyceride-esters: Compritol® 888 ATO and Precirol® ATO 5. They melt at relatively low temperatures and recrystallize quickly. They extrude well and can produce strand-like extrudates which can be down streamed into powders or granules.
These glyceride-esters can be used as release retarding agents/dissolution modifiers for both insoluble and soluble drugs even for high drug loading. In combination with plastic polymers they also can act as plasticizer/processing aid enabling lower temperature process and continuous production.
At Gattefossé we aim to share our knowledge to help formulators use lipid excipients to their best advantage.
Is Compritol® 888 ATO chemically stable in hot melt extrusion process at high temperature?
AAPS Annual Meeting and Exposition – San Diego (USA) - nov 2014
Ethanol resistant extended release matrix tablets with Compritol® 888 ATO
AAPS Annual Meeting and Exposition – San Diego (USA) - nov 2014
Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 6: Effects of Varying Pancreatin and Calcium Levels.
The AAPS Journal, volume 16, pages 1344–1357 DOI: 10.1208/s12248-014-9672-x - nov 2014
Effect of Tablet Structure on Controlled Release from Supersaturating Solid Dispersions Containing Glyceryl Behenate.
Mol. Pharmaceutics, 2015, 12 (1), pp 120–126 DOI: 10.1021/mp500480y - oct 2014
Solid lipid excipients — Matrix agents for sustained drug delivery
Journal of Controlled Release Volume 188, Pages 18–30 - aou 2014
This review article focuses on the utility of lipid excipients in solid sustained drug delivery systems with emphasis on the efficiency and robustness of these systems with respect to: (i) the choice of the manufacturing process and impact on drug release, (ii) the fundamental drug release mechanisms, (iii) resistance of the drug formulation under physiological conditions and (iv) long-term stability. Understanding the functionality of these versatile excipients in formulation is elementary for the development of highly robust lipid-based sustained release medicines
Streamlining the design of sustained release matrix tablets using mathematical modeling for drug release optimization
CRS Annual Meeting – Chicago (USA) - jui 2014