Nos publications
High shear blending with glyceryl distearate provides individually coated drug particles for effective taste masking
Journal of Drug Delivery Science and Technology, Volume 48, Pages 437-449 - déc 2018
In this study the authors used:
– A design of experiment, to evaluate the effect of process parameters (blending speed, chopper speed and coating time) on drug particle size.
– Potassium chloride as model drug.
The study showed:
– Individual particle coating was achieved at 450 rpm with 20% glyceryl distearate (Precirol® ATO 5) at 48°C
– High shear coating is as efficient as fluid bed coating for taste masking
– A trained sensory panel confirmed the effectiveness of the process on taste masking
TAM Technique for Identifying API-Lipid Excipient Compatibility Issues Upstream in the Development Process
AAPS PharmSci 360 – Washington DC (USA) - nov 2018
In this study the authors showed that Thermal Activity Monitoring is a useful technique to detect at early stage potential interaction between APi and excipients, using less time and resources than conventional techniques.
TAM technique is used routinely in Gattefossé North America Technical Center of Excellence to speed up formulation development.
Gelucire 48/16®: A Versatile Non-Ionic Solid Solubilizer for Tablets of Poorly Water-Soluble Drugs
AAPS PharmSci360 – Washington DC (USA) - nov 2018
A solid dispersion of ticagrelor and Gelucire® 48/16 is prepared to increase drug solubility . The solid dispersion is converted into tablets. The formulated tablets showed improved dissolution rate compared to the market reference.
A systematic approach to formulate and evaluate the stability of topical creams with high concentrations of Transcutol® HP
AAPS PharmSci 360 – Washington DC (USA) - nov 2018
In this study the authors developped stable anhydrous and hydrous creams containing 40% Transcutol® HP, using predictive techniques to select appropriate excipients.
Skin Penetration and Permeation Properties of Transcutol®—Neat or Diluted Mixtures
AAPS PharmSciTech, Vol. 19, No.8 DOI: 10.1208/s12249-018-1196-8 - nov 2018
In this critical article, the authors have reviewed numerous studies in order to elucidate the mechanism of action of the highly purified diethylene glycol monoethyl ether TRANSCUTOL® on skin penetration and permeation.
An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for Lipid-based Drug Delivery Systems
Pharmaceutical Research volume 36, Article number: 4 doi: 10.1007/s11095-018-2531-1. - nov 2018
In this review article, the authors describe the various technologies used for 3D printing and their application in the pharmaceutical field.
The potential for lipids and the opportunities for lipid-based drug delivery systems are highlighted.
Evolution of the Microstructure of Sustained-release Matrix Tablets during Dissolution and Storage
Indian J Pharm Sci 2018;80(6):1011-1020 - sep 2018
Solubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS
European Journal of Pharmaceutics and Biopharmaceutics, Volume 130, Pages 236-246 - sep 2018
A Novel Approach To Prepare Solid Self-microemulsifying Drug Delivery System Without A Solid-phase Carrier Using 3D Printing
CRS Annual Meeting – New York (USA) - jui 2018