Nos publications
Solid lipid Nanocarriers diffuse effectively through mucus and enter intestinal cells – but where is my peptide?
International Journal of Pharmaceutics, Volume 586, 119581 https://doi.org/10.1016/j.ijpharm.2020.119581 - aou 2020
This study aimed to evaluate the potential of Hydrophobic Ion Pairing combined with Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) to improve peptide transport across the intestinal border using Caco-2 cell monolayers (enterocyte-like model) and Caco-2/HT29-MTX co-cultured monolayers (mucin-secreting model).
This study showed that hydrophobic ion pairing enabled high encapsulation efficiency of peptide in SLN and NLC. The lipid-based nanocarriers were highly internalized by Caco-2 cell monolayers and were able to cross the mucus barrier (Caco-2/HT29-MTX cell model). However, the peptide intestinal transport was limited by an extensive release from the carriers.
Solid lipid nanocarrier development toolbox for increasing oral bioavailability of API
American Pharma Review, May-June 2020 issue, pp 69-75 - mai 2020
In this comprehensive article, the author describes the latest tools available to develop solid lipid nanoparticles: how to prepare and characterize solid lipid nanoparticles, how to evaluate encapsulation efficiency and intestinal permebility.
DOs and DON’Ts for developing successful SEDDS formulations to enhance API bioavailability
Tablets&Capsules, p.37-39 - avr 2020