Nos publications
Understanding The Role Of In Vitro And In Vivo Evaluation Techniques In Determining the Performance of Lipid-Based Formulations
CRS Annual Meeting – Valencia (Spain) - jui 2019
In this case study using curcuminoids as model drug, the authors show that in vitro lipolysis test is a useful tool to predict in vivo performance
Investigation of the permeation enhancer strategy on benzoylaconitine transdermal patch: the relationship between transdermal enhancement strength and physicochemical properties of permeation enhancer
Eur J Pharm Sci. 2019 Oct 1;138:105009. doi: 10.1016/j.ejps.2019.105009. Epub 2019 Jul 12. - jui 2019
In this study several permeation enhancers are evaluated for their ability to permeate high molecular weight benzoylaconitine. The results showed that Plurol® Oleique CC 497 enabled the highest permeation. FT-IR studies demonstrated that the enhancer had strong interactions with the Stratum corneum, both in the hydrophilic and lipophilic regions. The optimized patch formulation showed excellent analgesic and antiinflammatory effect.
In-vitro evaluation of solid lipid nanoparticles: Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract
International Journal of Pharmaceutics, Volume 565, Pages 409-418 - jui 2019
Investigation of Labrasol® ALF as an intestinal permeation enhancer: Ussing chambers and intestinal instillations
Poster presented at Keystone Symposia on Molecular and Cellular Biology – Delivering Therapeutics Across Biological Barriers (E1) - Dublin (Ireland) - mai 2019
A Proof of Concept for 3D Printing of Solid Lipid-Based Formulations of Poorly Water-Soluble Drugs to Control Formulation Dispersion Kinetics
Pharmaceutical Research volume 36, Article number: 102 doi: 10.1007/s11095-019-2639-y. - mai 2019
In this study, the authors show that solid SMEDDS can be produced with a 3D printing process and solid and semi-solid lipid excipients. The proof of concept is established with cinnarizine and fenofibrate as model drugs.
Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs
Advanced Drug Delivery Reviews, Volume 142, Pages 16-34 https://doi.org/10.1016/j.addr.2019.01.008 - mai 2019
In this review article, the authors explain the importance of the colloidal structures formed during dispersion and digestion of self emulsifying lipid-based formulations on drug solubilization and absorption.
A review of the techniques used to characterize the colloidal structures is also carried out.
An efficient method to determine the Hydrophile-Lipophile Balance of surfactants using the phase inversion temperature deviation of Ci Ej /n-octane/water emulsions.
International Journal of Cosmetic Science, 41, 99–108 doi: 10.1111/ics.12516 - avr 2019
Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis
International Journal of Pharmaceutics, Volume 559, Pages 228-234 - mar 2019
Lipids and polymers in pharmaceutical technology: Lifelong companions
International Journal of Pharmaceutics, Volume 558, 10 March 2019, Pages 128-142 - mar 2019
This article reviews the uses of lipids and polymers in pharmaceutical applications, alone or in combination, with a main focus on oral administration.
These topics were discussed at the Journées galéniques de Saint-Rémy de Provence in 2018, the Scientific Meeting sponsored by Gattefossé Foundation