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The Role of Lipids in Mitigation of Food Effect

  • Whitepaper

American Pharmaceutical Review - mar 2024

Inayet Ellis, Masumi Dave

In this paper, after a general description of the effect of food on gastrointestinal physiology, drugs, and formulation, the role of lipids is explained along with their digestion and absorption mechanisms. Case studies with self-emulsifying drug delivery systems (SEDDS) are presented as a way to mitigate the food effect. Current in vitro methods to determine indicators for the food effect during the drug development stage are also described.