Highest-purity solvent and solubilizer for solubility and bioavailability enhancement for oral and alternative routes.
Names & synonyms
| USP NF Name | Diethylene glycol monoethyl ether |
|---|---|
| EP Name | Diethylene glycol monoethyl ether |
| UNII Code (FDA) | A1A1I8X02B |
| Preferred Substance Name (FDA) | DIETHYLENE GLYCOL MONOETHYL ETHER |
| Handbook of Pharmaceutical Excipients | Diethylene glycol monoethyl ether |
| Chemical description | Consists of highly purified diethylene glycol monoethyl ether |
Key characteristics
| Product form | Liquid |
|---|---|
| Viscosity (mPa.s) | 4.8 (20°C) |
| HLB | Not applicable |
Main functionalities
Solvent and powerful solubilizer. Cosolvent in surfactant oral formulations—LFCS Type III (SMEDDS) and Type IV (micellar solutions). Safety of use and low irritancy inferred by numerous toxicological studies and precedence of use in approved pharmaceutical products.
Main formulation technologies
Self-emulsifying lipid formulation for oral applications. Soft/hard capsule filling.
Associated content
Excipients for solubility and bioavailability enhancement
Poor solubility, poor permeability, and pre-systemic elimination are factors that…
Lipid-based formulations
Lipid-based formulations are a powerful tool to increase oral bioavailability of…