A partially anionic oil-in-water emulsifier for topical formulations. It enables the formulation of anhydrous emulsions for hydrosensitive APIs and emulsions with solvents or large amount of oily phase.
Names & synonyms
| USP NF Name | Mixture of Triceteareth-4 phosphate and Ethylene glycol palmitostearate and Diethylene glycol palmitostearate |
|---|---|
| EP Name | Mixture of Triceteareth-4 phosphate and Ethylene glycol palmitostearate and Diethylene glycol palmitostearate |
| UNII Code (FDA) | / 0324G66D0E 94YQ11Y95F |
| Preferred Substance Name (FDA) | / GLYCOL STEARATE PEG-2 STEARATE |
| Handbook of Pharmaceutical Excipients | Ethylene Glycol Palmitostearate |
| Chemical description | Consits of a mixture of triceteareth-4 phosphate, ethylene glycol esters of palmitic (C16) end stearic (C18) acids and diethylene glycol esters of palmitic (C16) end stearic (C18) acids |
Key characteristics
| Product form | Pellets |
|---|---|
| Melting range (°C) | 47 - 52 |
| HLB | 10 |
Main functionalities
Emulsifier for anhydrous topical formulations. Emulsifier for difficult-to-formulate emulsions (solvents and large oily phase). Stabilizes and improves sensorial and texture properties. Safety of use is inferred by precedence of use in approved pharmaceutical products.
Main formulation technologies
Topical emulsion and foam (with aerosol). One-pot formulation process can facilitate manufacturing.
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