All publications

Toward improving the in vitro in vivo correlation of lipid-based formulations using a simplified gastro-intestinal lipolysis protocol

  • Poster

AAPS - Oct 2024

Elise Dauphin-Chanard, Stéphanie Chevrier, Malaury Ducros, Philippe Caisse

Lipid-based formulations (LBF) enhance the oral bioavailability of poorly water-soluble drugs by maintaining them in a solubilized state during digestion. This study aims to establish a robust protocol to evaluate the impact of gastro-intestinal lipolysis on LBF performance, using cinnarizine as a model drug.

Download (.pdf - 516.39 KB)

In-vitro investigation regarding the effects of Gelucire® 44/14 and Labrasol® ALF on the secretory intestinal transport of P-gp substrates

  • Scientific publication

International Journal of Pharmaceutics, Volume 515, Issues 1–2, Pages 293-299 https://doi.org/10.1016/j.ijpharm.2016.10.012 - Dec 2016

Océane Dubray, Vincent Jannin, Fréderic Demarne, Yann Pellequer, Alf Lamprecht, Arnaud Béduneau

Establishment of a binary phase diagrams database for the development of self-emulsifying lipid-based formulations

  • Poster

AAPS Annual Meeting and Exposition – San Diego (USA)  - 2014

Jannin, Vincent; Benhaddou, Hamza; Dumont, Camille; Chevrier, Stéphanie; Chavant, Yann; Demarne, Frédéric

Self-formulation protocol: Part II: excipient selection, diagram design and selection of prototype formulations.

  • Poster

AAPS Annual Meeting and Exposition - San Antonio (USA)  - Nov 2013

Jannin, Vincent; Michenaud, Mathieu; Belotti, S.; André, C.; Chevrier, Stéphanie; Chavant, Yann et al. (2013)

Dispersion test and ternary diagramming are detailed, to determine the excipient ratios and prototype formulations 

Download (.pdf - 785.65 KB)

Self-formulation protocol: Part III: impact of lipolysis on prototype formulations

  • Poster

AAPS Annual Meeting and Exposition - San Antonio (USA)  - 2013

Jannin, Vincent; Michenaud, Mathieu; Belotti, S.; André, C.; Chevrier, Stéphanie; Chavant, Yann et al. (2013)

Lipolysis test is used to determine the capacity of prototype formulations to maintain drug in solubilized state. 

Download (.pdf - 1.46 MB)

Self-formulation protocol: Part I: Solubility determination in liquid and solid excipients

  • Poster

AAPS Annual Meeting and Exposition – San Antonio (USA)  - 2013

Jannin, Vincent; Michenaud, Mathieu; Belotti, S.; André, C.; Chevrier, Stéphanie; Chavant, Yann et al.

Dispersion test and ternary diagramming are detailed, to determine the excipient ratios and prototype formulations 

Download (.pdf - 400.94 KB)