Skin biology
Gattefossé opened a cell biology laboratory, including clean rooms, at its headquarters in 2013. The laboratory technicians and scientists work on skin cells and tissues and carry out research in skin biology aimed at developing cosmetic substantiation tests and innovative investigative models.
Cell culture models to substantiate cosmetic active ingredients
Our active ingredients are substantiated through a set of efficacy tests adapted to molecular screening:
- Simple models of monolayer cell culture (fibroblasts, keratinocytes, melanocytes, adipocytes, and sebocytes) are used to investigate the efficacy of active ingredients on cell metabolism (cell proliferation and protein synthesis),
- Pluristratified models, such as spheroid cultures, are developed to reach matrix targets and complete the screening process.
3D models of artificial skin
We also work with advanced 3D artificial skin models and reconstructed epidermis, dermis, and skin. Human skin biopsies are used to mimic skin physiology and isolate innovative biological mechanisms and targets. These models enable identification of the mechanisms of action and biological properties of our active ingredients.
Innovation through research in skin biology
Our skin biology research, conducted in partnership with academic research institutes, provides us with technologies at the cutting edge of innovation. 3D artificial skin cultures not only serve to demonstrate efficacy, but also function as investigative models to acquire a better understanding of skin pathophysiology (aging, UV, pollution, and stress) and discover new cosmetic targets for the development of active ingredients.
Gattefossé expertise in cell culture and tissue engineering is matched by biochemical, enzymological and immunological methods as well as microscopy and image analysis.