All publications
Advantages of combining cellulosic polymers and lipids in extruded 3D printing filaments. Part II 3D printing (FDM) and printlets characterization
PBP - Mar 2026
In this second poster of this collaboration between Gattefossé, ShinEtsu and ThermoFisher, various combinations of lipid excipients and TYLOPUR® 605 (Hypromellose 2910) were extruded, printed with an active pharmaceutical ingredient (API), and comprehensively characterized.
Formulation Strategies to Improve Drug Absorption: The Role of Lipid-Based Formulations and Permeation Enhancers
PBP - Mar 2026
This work compared ticagrelor permeability in Caco-2 monolayers versus Caco-2/HT29-MTX (70:30) co-cultures to assess the impact of mucus and how lipid excipients modulate intestinal permeability.
Predicting API solubility in lipid excipients a combined PC-SAFT and experimental approach for enhanced oral delivery
PBP - Mar 2026
The study investigates the predictive ability of the PC-SAFT thermodynamic model, implemented in the Siemens gPROMS FormulatedProducts platform, to estimate drug solubility in lipid excipients.
Lipid excipients as key modulators of the apparent intestinal permeability in lipid-based formulations: Insights from Caco-2 and Caco-2/HT29-MTX models
European Journal of Pharmaceutics and Biopharmaceutics - Mar 2026
In this publication, we explore how lipid-based formulations enhance drug solubilization and permeability, and how adding permeation enhancers further boosts absorption. Mucus-containing models showed lower but more physiologically relevant permeability, underscoring the importance of excipient choice and ratios in formulation design.
Beyond the capsule: Unlocking the full potential of lipid excipients in oral solid dosage forms
Jan 2026
In this whitepaper, Gattefossé Pharmaceuticals seeks to bridge the gap between lipid-based formulations and oral solid dosage forms, demonstrating the utility and potential of incorporating lipid excipients into modern tablet development.
The influence of key formulation and processing parameters on high-shear granulation
American Pharmaceutical Review - Feb 2026
High‑shear granulation plays a vital role in developing and manufacturing oral solid dosage forms. The whitepaper explains how to fine‑tune equipment settings, formulation choices, and particle properties to optimize granulation and leverage functional excipients that enhance tablet performance.
Unlocking oral peptide and protein delivery with a lipid-based approach
American Pharmaceutical Review - Sep 2025
The oral delivery of therapeutic peptides and proteins is hindered by enzymatic degradation and poor permeability. This whitepaper explores Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC), advanced delivery systems that enhance drug loading, absorption, stability, and protection against gastric degradation. The types, applications, and efficacy of these systems are discussed and highlighted through relevant case studies.
Impact of gastric phase simulation on the in vitro lipolysis of lipid-based formulations containing ticagrelor and fenofibrate
AAPS - Nov 2025
The study examines how adding a simulated gastric phase before intestinal lipolysis affects the solubilization of two lipophilic drugs, highlighting that gastric digestion improves in vitro prediction of pharmacokinetics and formulation discrimination.
Assessing the performance of lipids as surfactants to enhance the release profile of a model BCS class IV compound from ASD
AAPS - Nov 2025
This study aimed to develop Amorphous Solid Dispersions (ASDs) of anacetrapib, a lipophilic BCS class IV drug, using Hot Melt Extrusion (HME) with lipid-based excipients as surfactants to improve dissolution. A secondary goal was to establish a robust method for incorporating solid or semi-solid excipients into powder blends for HME without requiring specialized feeding ports.