Pharmaceuticals
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Excipients for pharmaceuticals and veterinary drugs, and dietary supplements.
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Capryol® 90
Read moreLatest News
Unveiling the Potential of Labrasol® ALF Labrafac™ MC60 and Capryol® 90 as Permeation Enhancers to Address Low Bioavailability Issues
Oct 2024
In vitro, ex vivo, and in vivo tests show that Labrasol® ALF, Labrafac™ MC60, and Capryol® 90 are effective and safe permeation enhancers. They work by temporarily opening tight junctions in the intestinal lining, potentially improving the bioavailability of poorly permeable drugs, including small molecules (BCS III and IV) and large molecules like peptides and proteins.
Platform technology for introducing liquid solubilizers in tablet formulations
Oct 2024
Lipid-based excipients, which are often liquid at room temperature, can enhance solubility and permeation. This study aims to incorporate a liquid lipid excipient into a solid dosage form for the poorly water-soluble drug ondansetron hydrochloride dihydrate (OHD).
Toward improving the in vitro in vivo correlation of lipid-based formulations using a simplified gastro-intestinal lipolysis protocol
Oct 2024
Lipid-based formulations (LBF) enhance the oral bioavailability of poorly water-soluble drugs by maintaining them in a solubilized state during digestion. This study aims to establish a robust protocol to evaluate the impact of gastro-intestinal lipolysis on LBF performance, using cinnarizine as a model drug.
- Lipolysis test