All publications

A Novel Approach To Prepare Solid Self-microemulsifying Drug Delivery System Without A Solid-phase Carrier Using 3D Printing

  • Poster

CRS Annual Meeting – New York (USA)  - Jul 2018

KapilkumarVithani, Alvaro Goyanes, Vincent Jannin, Simon Gaisford, Ben Boyd

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The Gelucire® family

  • Whitepaper

Pharma Excipients  - 2018

Gattefossé

Size characterization of lipid-based self-emulsifying pharmaceutical excipients during lipolysis using Taylor dispersion analysis with fluorescence detection

  • Scientific publication

International Journal of Pharmaceutics, Volume 537, Issues 1–2, Pages 94–101 - Feb 2018

Joseph Chamieh, Habib Merdassi, Jean-Christophe Rossi, Vincent Jannin, Frédéric Demarne, Hervé Cottet

In this work, the lipolysis of Labrasol® and Gelucire® 44/14 , two lipid based self-emulsifying drug delivery systems, by pancreatic enzymes and under conditions mimicking the gastrointestinal tract is followed by Taylor dispersion analysis. Results show that, Labrasol® droplets decrease exponentially in size with lipolysis time, whereas Gelucire® 44/14 droplets increased sigmoïdally in size. Even after 120 min lipolysis, both systems maintain a solubilizing capacity of the hydrophobic marker.