All publications
Unveiling the Potential of Labrasol® ALF Labrafac™ MC60 and Capryol® 90 as Permeation Enhancers to Address Low Bioavailability Issues
American Pharmaceutical Review - Oct 2024
In vitro, ex vivo, and in vivo tests show that Labrasol® ALF, Labrafac™ MC60, and Capryol® 90 are effective and safe permeation enhancers. They work by temporarily opening tight junctions in the intestinal lining, potentially improving the bioavailability of poorly permeable drugs, including small molecules (BCS III and IV) and large molecules like peptides and proteins.
Establishment of a binary phase diagrams database for the development of self-emulsifying lipid-based formulations
AAPS Annual Meeting and Exposition – San Diego (USA) - 2014
Self-formulation protocol: Part II: excipient selection, diagram design and selection of prototype formulations.
AAPS Annual Meeting and Exposition - San Antonio (USA) - Nov 2013
Dispersion test and ternary diagramming are detailed, to determine the excipient ratios and prototype formulations
Self-formulation protocol: Part I: Solubility determination in liquid and solid excipients
AAPS Annual Meeting and Exposition – San Antonio (USA) - 2013
Dispersion test and ternary diagramming are detailed, to determine the excipient ratios and prototype formulations
Self-formulation protocol: Part III: impact of lipolysis on prototype formulations
AAPS Annual Meeting and Exposition - San Antonio (USA) - 2013
Lipolysis test is used to determine the capacity of prototype formulations to maintain drug in solubilized state.