All publications
Formulation forum – A Quick Approach for Evaluation of Drug-Excipient Compatibility: Case of Acetylsalicylic Acid
Drug Development & Delivery - 2021
In this study, the authors monitor acetylsalicylic acid (ASA) hydrolysis in different formulations using UPLC and TAM with the objective of comparing these methods for agreement, speed, and efficiency in predicting drug stability. In parallel, we assess the impact of the excipient choices on the stability of the ASA.
TAM Technique for Identifying API-Lipid Excipient Compatibility Issues Upstream in the Development Process
AAPS PharmSci 360 – Washington DC (USA) - Nov 2018
In this study the authors showed that Thermal Activity Monitoring is a useful technique to detect at early stage potential interaction between APi and excipients, using less time and resources than conventional techniques.
TAM technique is used routinely in Gattefossé North America Technical Center of Excellence to speed up formulation development.