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Comparing the effect of adding Gelucire® 48/16 and Gelucire® 50/13 in amorphous solid dispersion: a case study with ticagrelor

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CRS - Jul 2024

Lolie Chéron, Cédric Miolane, Philippe Caisse

When amorphous solid dispersion (ASD) are produced by hot melt extrusion (HME), the use of a neat polymer requires high process temperatures, and the drug release is not always complete. Adding Gelucire® in the formula is a promising strategy to address these issues.