Hard fats for pessaries
Pessary, sometimes described as vaginal suppository, is the most common dosage form used for vaginal drug delivery of anti-fungals, antibiotics, corticosteroids, hormones or hydrating agent.
Vaginal drug delivery, for local and systemic action
The vaginal mucosa is highly sensitive, and this is even more exacerbated when a pathological condition is declared. Vaginal dosage forms should be developed with excipients providing great mucosal tolerance, no-irritancy, and safety of use.
Our hard fat bases Ovucire® have proven safety and mucosal tolerance, excellent drug dispersion and physicochemical stability, narrow melting range for high performance in vivo and a solidification behavior adapted for a wide range of manufacturing equipment. Ovucire® are ideal vehicles for pessaries.
Although very efficient, pessaries should not be considered as the sole dosage form for vaginal treatments. Curing vaginal diseases often combine the use of a pessary inside the vaginal cavity, and the use of a topical cream or gel externally. Preventing vaginal diseases with the use of probiotics is developing, with combine use of pessary and cream.
Dedicated bases for pessaries
Our Ovucire® range of hard fat bases for pessaries has been optimized for vaginal drug delivery purposes:
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a melting temperature around 34°C, targeting the human vaginal temperature
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a high hydroxyl value which favors spreadability across the vaginal membranes
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use of an additive enabling homogeneous dispersion of the API in the dosage
Ovucire® Grade Ovucire® Main Characteristics Ovucire® 3460 Good mechanical resistance and enhanced spreadability within the vaginal cavity Ovucire® WL 3264 With additive to enhance API dispersion and wettability
Suppocire® can also be used to formulate pessaries; please consult the dedicated page to discover the full range
