A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.
Names & synonyms
| USP NF Name | Propylene Glycol Mono and Dicaprylate NF |
|---|---|
| EP Name | / |
| UNII Code (FDA) | RT9P9S09QI |
| Preferred Substance Name (FDA) | PROPYLENE GLYCOL CAPRYLATE |
| Handbook of Pharmaceutical Excipients | Propylene glycol monocaprylate |
| Chemical description | Consists of propylene glycol esters of caprylic acid (C8), composed of mono- and diesters. |
Key characteristics
| Product form | Oily liquid |
|---|---|
| Viscosity (mPa.s) | 20 (20°C) |
| HLB | 6 |
Main functionalities
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Co-surfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations.
Solubilizer and skin penetration enhancer. Co-surfactant for microemulsion in topical formulation.
Safety of use is inferred by precedence of use in approved pharmaceutical products.
Main formulation technologies
- Oral applications: self-emulsifying lipid formulation
- Topical emulgel, microemulsion and patches
Documentation
Documentation technique
Associated content
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