Noxifense™

Soothing with every drop

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Description

Noxifense™ is a novel 100% plant-derived bioactive that targets the thriving market of sensitive skin. 

Rich in antioxidant and anti-inflammatory polyphenols, it tackles the phenomenon of oxi-inflammation at 360°. More specifically, it calms the oxi-inflammatory environment generated by lipoperoxidation and provides a shot of antioxidant defense to the skin. It has been clinically proven to soothe the most reactive and sensitive skin. 

Claims

• Breaks the oxi-inflammation loop 
• Acts as a barrier against the exposome 
• Antioxidant and anti-inflammatory 
• Soothes sensitive, reactive skin
• Improves skin glow, texture, and comfort 

  • 1%

  • COSMOS certified
    Natural origin (ISO 16128): 100%
    Preservative free

  • Propanediol (and) Hippophae Rhamnoides Extract

    China NMPA notified

The ingredient video summary

Mechanism of action

cytokines expression in stratum corneum

The recent concept of oxi-inflammation underscores the ongoing and self-sustaining cycle between oxidation and inflammation. Skin lipids are highly susceptible to oxidation and are the primary seat of oxi-inflammatory environment. 

Through sophisticated modeling of lipoperoxidation-induced inflammation, Noxifense™ has been proven to calm the oxi-inflammatory environment induced by the oxidation of lipids, both in the stratum corneum and the living epidermis. 

Besides, Noxifense™ acts through the NF-kB pathway to prevent inflammation. It also features impressive capacity to boost the internal antioxidant defense system for a proven reduction in intracellular ROS levels. 

Clinical evaluation

Before after pictures - skin redness with Noxifense

In a clinical study on Asian volunteers with sensitive skin, Noxifense™ reduced stinging sensations and soothed the skin. 

Panelists confirmed it improves their overall skin comfort, texture, and color, allowing them to say goodbye to redness and hello to smooth, radiant skin!

Sourcing

Noxifense™ is a 100% plant-based bioactive derived from sea-buckthorn, a resilient and nutrient-rich plant celebrated for its abundance of antioxidant and anti-inflammatory polyphenols. Gattefossé successfully captured these benefits thanks to its long-standing expertise in plant chemistry. More precisely, flavonol glycosides and ellagitannins play an active role in the antioxidant and anti-inflammatory properties of this bioactive.

Embracing upcycling principles, Gattefossé transforms the overlooked leaves sourced from a family-owned orchard in Quebec, Canada, devoted to sustainable farming. 

 

 

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