All publications
Solubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS
European Journal of Pharmaceutics and Biopharmaceutics, Volume 130, Pages 236-246 - Sep 2018
Inclusion of digestible surfactants in solid SMEDDS formulation removes lag time and influences the formation of structured particles during digestion
The AAPS Journal, Vol. 19, No. 3 - May 2017
The objective of this study is to evaluate how solid self-microemulsifying drug delivery systems (SMEDDS) behave during digestion. SMEDDS containing Gelucire® 44/14 and surfactants were prepared and their dispersion and digestion behaviors were studied using an in vitro lipolysis model, coupled with small-angle X-ray scattering (SAXS) to determine the formed colloidal structures during digestion in real time.
The study shows that the lipid to surfactant ratio has a significant effect on the kinetics of digestion and an optimum ratio is prerequisite to develop rapidly digestible solid SMEDDS system.