All publications
Skin Penetration and Permeation Properties of Transcutol® in Complex Formulations
AAPS PharmSciTech - Sep 2024
The review examines how hydroalcoholic solvents, especially Transcutol, enhance drug delivery in multi-component formulations. It highlights factors like drug diffusion, solubilization, and skin absorption, focusing on the interaction between drug properties, skin barrier, and formulation for effective (trans)dermal delivery.
Labrafac™ MC60 is an efficacious intestinal permeation enhancer for macromolecules: Comparisons with Labrasol® ALF in ex vivo and in vivo rat studies
International Journal of Pharmaceutics - Jun 2024
In this article, demonstration on how Labrafac™ MC60 acts as a safe intestinal permeation enhancer is given, with insulin as a model molecule. Studies were conducted in vivo and ex vivo, using isolated muscle-stripped rat jejunal and colonic mucosae.
Establishment of a continuous inline-monitored nano-production line using the Microfluidizer® technology for the fabrication of safe lipid-based nanoparticles
Macedonian Pharmaceutical Bulletin - Sep 2023
Nano-drug delivery systems (NDDS) serve as a promising platform in modern medicine, facilitating the targeted delivery of drugs due to their versatile size, structure, and composition. However, the current industrial production of NDDS relies on cumbersome batch processes that are costly, difficult to scale, and lack adequate control. This study focuses on enhancing industrial-scale production through the development and testing of a continuous top-down production line, utilizing scalable Microfluidizer® technology for solvent-free preparation of lipid-based nanoparticles.
Self-emulsifying drug delivery systems (SEDDS): In vivo-proof of concept for oral delivery of insulin glargine
International Journal of Pharmaceutics 639 - 122964 - May 2023
In this study, lipophilicity of insulin glargine (IG) was successfully increased via hydrophobic ion pairing (HIP) with sodium octadecyl sulfate to enable incorporation into self-emulsifying drug delivery systems (SEDDS). The SEDDS formulations F1 and F2 were administered to rats via oral gavage and resulted in a bioavailability of 0.55% and 0.44%, corresponding to a 7.7-fold and 6.2-fold increased bioavailability, respectively. Thus, incorporation of complexed insulin glargine into SEDDS formulations provides a promising approach to facilitate its oral absorption.
Formulation et fabrication des suppositoires [Formulation and manufacturing of suppositories].
Techniques de l’Ingénieur - Oct 2022
Formulation et fabrication des suppositoires [Formulation and manufacturing of suppositories].
Techniques de l’Ingénieur - Oct 2022
Effect of Lipid Vehicles on Solubility, Stability, and Topical Permeation of Delta 9 Tetrahydrocannabinol
AAPS PharmSciTech, 23:223 - Jul 2022
Lipid-based nanocarriers for oral delivery of peptides
OCL, Volume 29, 1 https://doi.org/10.1051/ocl/2021040 - Jan 2022
Carving out a Niche in Pharmaceutical Drug Delivery
Pharma Times – Vol. 53 – No. 12 - Dec 2021