All publications
Unveiling the Potential of Labrasol® ALF Labrafac™ MC60 and Capryol® 90 as Permeation Enhancers to Address Low Bioavailability Issues
American Pharmaceutical Review - Oct 2024
In vitro, ex vivo, and in vivo tests show that Labrasol® ALF, Labrafac™ MC60, and Capryol® 90 are effective and safe permeation enhancers. They work by temporarily opening tight junctions in the intestinal lining, potentially improving the bioavailability of poorly permeable drugs, including small molecules (BCS III and IV) and large molecules like peptides and proteins.
The Role of Lipids in Mitigation of Food Effect
American Pharmaceutical Review - Mar 2024
In this paper, after a general description of the effect of food on gastrointestinal physiology, drugs, and formulation, the role of lipids is explained along with their digestion and absorption mechanisms. Case studies with self-emulsifying drug delivery systems (SEDDS) are presented as a way to mitigate the food effect. Current in vitro methods to determine indicators for the food effect during the drug development stage are also described.