All publications
Unveiling the Potential of Labrasol® ALF Labrafac™ MC60 and Capryol® 90 as Permeation Enhancers to Address Low Bioavailability Issues
American Pharmaceutical Review - Oct 2024
In vitro, ex vivo, and in vivo tests show that Labrasol® ALF, Labrafac™ MC60, and Capryol® 90 are effective and safe permeation enhancers. They work by temporarily opening tight junctions in the intestinal lining, potentially improving the bioavailability of poorly permeable drugs, including small molecules (BCS III and IV) and large molecules like peptides and proteins.
The Role of Lipids in Mitigation of Food Effect
American Pharmaceutical Review - Mar 2024
In this paper, after a general description of the effect of food on gastrointestinal physiology, drugs, and formulation, the role of lipids is explained along with their digestion and absorption mechanisms. Case studies with self-emulsifying drug delivery systems (SEDDS) are presented as a way to mitigate the food effect. Current in vitro methods to determine indicators for the food effect during the drug development stage are also described.
An All-Purpose Vehicle for Low-Energy Capsule Filling
Tablets&Capsules - Apr 2023
Capsules are perceived as elegant, easy-to-swallow dosage forms, widely used for delivery of nutraceutical and medicinal preparations. Advances in capsule technologies have hugely facilitated the incorporation of liquid, semi-solid, and solid ingredients into capsules.
LIPID-BASED EXCIPIENTS – Misconceptions About Lipid-Based Drug Delivery
Drug Development & Delivery - Apr 2023
Cannabinoid molecules and their love of lipid excipients
Pharmaceuticals & Cosmetic Review - Feb 2022
Formulation forum – A Quick Approach for Evaluation of Drug-Excipient Compatibility: Case of Acetylsalicylic Acid
Drug Development & Delivery - 2021
In this study, the authors monitor acetylsalicylic acid (ASA) hydrolysis in different formulations using UPLC and TAM with the objective of comparing these methods for agreement, speed, and efficiency in predicting drug stability. In parallel, we assess the impact of the excipient choices on the stability of the ASA.
Solid lipid nanocarrier development toolbox for increasing oral bioavailability of API
American Pharma Review, May-June 2020 issue, pp 69-75 - May 2020
In this comprehensive article, the author describes the latest tools available to develop solid lipid nanoparticles: how to prepare and characterize solid lipid nanoparticles, how to evaluate encapsulation efficiency and intestinal permebility.
DOs and DON’Ts for developing successful SEDDS formulations to enhance API bioavailability
Tablets&Capsules, p.37-39 - Apr 2020
A snapshot of lipid excipients for topical formulations
Pharma Times – Vol. 51 – No. 59 - Sep 2019
Lipid excipients in pharmaceutical technologies
Nabil FARAH and Joel DENIS
Lipidic excipients in drug delivery for solubility and bioavailability enhancement
Prashantkumar K. PARMAR, Srilaxmi G. RAO, Arvind KK. BANSAL
From exploration of lipids to its exploitation in market: Pharmaceuticals, Nutraceuticals and Herbal
Saurabh ARORA, Abhinav GARG, Karishma KAPOOR
A snapshot of lipid excipients for topical formulations
Renuka TIWARI, Ketkee DESHMUKH, Agnivesh SHRIVASTAVA, Kanchan KOHLI
Strategic lipid-based delivery interventions for enhancing oral bioavailability of BCS II/IV drugs
Teenu SHARMA, Ranjot KAUR, Sumant SAINI, Atul JAIN, Bhupinder SINGH
Unleashing role of excipients in overcoming formulation challenges
Meenakshi VENKATARAMAN, Megha MARWAH, Mangal NAGARSENKER
Role of lipid excipients in oral sustained release drug delivery systems
Divya JAIN, Namita DESAI
