All publications
Synergising excipients to boost skin delivery
ONdrugDelivery Magazine, Issue 99, pp 54-58. - Aug 2019
This article focuses on Transcutol® P, Capryol® and Lauroglycol™ as their synergism brings eye-opening benefits in topical formulations.
High shear coating: a versatile taste-masking process
ONdrugDelivery Magazine, Issue 88, pages 10-13 - Jul 2018
Copyright © 2018 Frederick Furness Publishing Ltd
The Gelucire® family
Pharma Excipients - 2018
Complex Interplay between Solubilization, Digestion, Supersaturation and Absorption of Poorly Soluble Drugs with Lipid-Based Formulations
Current Drug Delivery, 2018, 15, 749-751 - 2018
LIPID-BASED DELIVERY – Are Lipid-Based Drug Delivery Systems in Your Formulation Toolbox?
Drug Development & Delivery, Vol. 17, No. 7, p.20-25 - Oct 2017
This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.
Amélioration de la biodisponibilité des substances actives via la formulation [Bioavailability enhancement of active pharmaceutical ingredients through formulation strategies] galénique
STP Pharma Pratiques, Mai-Juin 2017, n°1 - 2017
The SFSTP commission on Bioavailability published an article reviewing the formulation strategies to enhance the bioavailability of APIs.
Interestingly this article is both in French and English languages.
Table of content:
I Introduction
II Prerequisites
1 Initial identification and characterization of the active ingredient
1.1 Physico-chemical characteristics
1.2 Impact of physicochemical characteristics on absorption
1.3 Passive diffusion prediction tools
1.4 In silico prediction
2 Biopharmaceutical classifications
III Formulation strategies
1 Prerequisites
2 Techniques for increasing the dissolution rate
3 Solubility enhancement technologies
4 Improving the permeability, oral route
IV Control, assessment, prediction of the bioavailability
1 Physicochemical control methods for the manufacturing intermediates and finished products
2 Assessing and predicting the bioavailability of the formulations
V Alternative strategy: changing the route of administration
VI Conclusion: decision tree
Gelucire® 48/16: a solid surfactant for tablets
Pharma Times, Vol. 48 – N° 11 – pp 17-22 - Nov 2016
This article describes Gelucire® 48/16 – a novel pegylated lipid excipient, and its use as a solid surfactant for solubility enhancement.
Experience foam for topical drug delivery
Nov 2016
Pharmaceutical foams are becoming more popular probably due to more topical medicines being switched to OTC and the need to innovate and differentiate ‘brands’ and an increasing awareness of the importance of formulating to deliver sensorial benefits and positive impact on patient experience and adherence. Gattefossé, as a leading provider of excipients for the pharmaceutical industry, manufactures solubilizers and texturizers for skin drug delivery. In this white paper we give formulation tips for propellant and propellant-free foams with guidelines on how to formulate and select excipients and case studies with model drugs.
Maisine® CC, a unique pharmaceutical oil for solubility and oral bioavailability enhancement
Gattefossé - Oct 2016
This white paper features Maisine® CC (glyceryl monolinoleate NF), a unique pharmaceutical oil that has a long and successful history of use in lipid-based formulation for drug solubilization and oral bioavailability enhancement.