Lauroglycol™ 90

Access documents and technical information

A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.

Names & synonyms

USP NF Name

Propylene glycol monolaurate (type II)
EP Name

Propylene glycol monolaurate (type II)
UNII Code (FDA)

668Z5835Z3
Preferred Substance Name (FDA)

PROPYLENE GLYCOL LAURATES
Handbook of Pharmaceutical Excipients

Propylene glycol monolaurate
Chemical description

Consists of propylene glycol mono- and di- esters of lauric (C12) acid, mainly composed of monoesters and a small fraction of diesters

Key characteristics

Product form

Liquid
Viscosity (mPa.s)

25 (20°C)
HLB

3

Main functionalities

Solubilizer for poorly-soluble APIs and bioavailability enhancer. Co-surfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations.

Solubilizer and skin penetration enhancer. Co-surfactant for microemulsion in topical formulation.

Safety of use is inferred by precedence of use in approved pharmaceutical products.

Main formulation technologies

Self-emulsifying lipid formulation for oral applications. Topical emulgel, microemulsion.

Resources

Technical documentation

Brochures

Scientific document

Associated content

Excipients for solubility and bioavailability enhancement

Poor solubility, poor permeability, and pre-systemic elimination are factors that…

Solubilizing drugs for skin delivery, a decisive step

Selecting penetration enhancers, for transdermal delivery

To overcome the skin barrier properties, many strategies exist, among which the use…