A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.
Names & synonyms
| USP NF Name | Propylene glycol monolaurate (type II) |
|---|---|
| EP Name | Propylene glycol monolaurate (type II) |
| UNII Code (FDA) | 668Z5835Z3 |
| Preferred Substance Name (FDA) | PROPYLENE GLYCOL LAURATES |
| Handbook of Pharmaceutical Excipients | Propylene glycol monolaurate |
| Chemical description | Consists of propylene glycol mono- and di- esters of lauric (C12) acid, mainly composed of monoesters and a small fraction of diesters |
Key characteristics
| Product form | Liquid |
|---|---|
| Viscosity (mPa.s) | 25 (20°C) |
| HLB | 3 |
Main functionalities
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Co-surfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations.
Solubilizer and skin penetration enhancer. Co-surfactant for microemulsion in topical formulation.
Safety of use is inferred by precedence of use in approved pharmaceutical products.
Main formulation technologies
Self-emulsifying lipid formulation for oral applications. Topical emulgel, microemulsion.
Resources
Technical documentation
Brochures
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Gattefosse brochure Selecting the best excipients to optimize drug delivery
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Gattefosse brochure Lipid excipients for cannabinoid drug products
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Gattefosse brochure Oral drug delivery with lipid excipients
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Gattefosse Brochure Skin-Friendly Textures
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Gattefosse brochure veterinary medicines with Lipid excipients
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Brochure Gattefosse Lipid-based formulations Bio-enhancers by nature
Scientific document
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Poster AAPS 2013: Self formulation protocol I Solubiity determination in liquid and solid excipient
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Poster AAPS 2013: SELF formulation protocol II Excipient selection diagram design and selection of prototype formulations
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Poster AAPS 2013: SELF formulation protocol III Impact of lipolysis on prototype formulations
Associated content
Excipients for solubility and bioavailability enhancement
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