A winterized oil composed of long-chain mono-, di-, and triglycerides for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble lipophilic APIs. Used in self-emulsifying lipid formulations (SEDDS and SMEDDS) as an oily vehicle.
Names & synonyms
| USP NF Name | Glyceryl monolinoleate |
|---|---|
| EP Name | Glycerol monolinoleate |
| UNII Code (FDA) | 4763AXI84L |
| Preferred Substance Name (FDA) | GLYCERYL MONOLINOLEATE |
| Handbook of Pharmaceutical Excipients | Glyceryl monolinoleate |
| Chemical description | Consists of mono-, di- and triglycerides of mainly linoleic (C18:2) and oleic (C18:1) acids, the diester fraction being predominant |
Key characteristics
| Product form | Liquid |
|---|---|
| Viscosity (mPa.s) | 120 (20°C) |
| HLB | 1 |
Main functionalities
Solubilizer for lipophilic API and bioavailability enhancer. Oily vehicle for LFCS Type I (oily), Type II (SEDDS) and Type III (SMEDDS), associated with lymphatic absorption. Safety of use is inferred by GRAS status and precedence of use in approved pharmaceutical products.
Main formulation technologies
Oily and self-emulsifying lipid formulation for oral applications. Soft/hard gelatin capsule filling.
Resources
Technical documentation
Brochures
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Gattefosse brochure Selecting the best excipients to optimize drug delivery
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Gattefosse brochure Maisine CC a pharmaceutical oil for solubility and oral bioavailability enhancement (En)
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Gattefosse brochure Lipid excipients for cannabinoid drug products
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Gattefosse brochure Oral drug delivery with lipid excipients
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Brochure Gattefosse Lipid-based formulations Bio-enhancers by nature
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