Hard fat suppository base with high crystallization rate, incorporating phospholipids to facilitate high drug loading.
Names & synonyms
| USP NF Name | Hard fat with additive (lecithin) |
|---|---|
| EP Name | Hard fat with additive |
| UNII Code (FDA) | Not applicable |
| Preferred Substance Name (FDA) | Fat, hard |
| Handbook of Pharmaceutical Excipients | Suppository bases, hard fat |
| Chemical description | Consists of mono-, di- and triglyceride esters of fatty acids (C10 to C18), the triester fraction being predominant and containing lecithin |
Key characteristics
| Product form | Pellets |
|---|---|
| Melting range (°C) | 34 - 38 |
| Hydroxyl value (mg KOH/g) | <10 |
Main functionalities
Facilitates dispersion of large concentrations of APIs. Recrystallizes rapidly.
Main formulation technologies
Suppository molding.
Resources
Associated content
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