Hard fat suppository base optimized for the formulation of analgesics and antipyretics. Confers high mechanical resistance and yields harder suppository units.
Names & synonyms
| USP NF Name | Hard fat |
|---|---|
| EP Name | Hard fat |
| UNII Code (FDA) | 8334LX7S21 |
| Preferred Substance Name (FDA) | Fat, hard |
| Handbook of Pharmaceutical Excipients | Suppository bases, hard fat |
| Chemical description | Consists of mono-, di- and triglyceride esters of fatty acids (C10 to C18), the triester fraction being predominant |
Key characteristics
| Product form | Pellets |
|---|---|
| Melting range (°C) | 33 - 35 |
| Hydroxyl value (mg KOH/g) | 20 - 30 |
Main functionalities
Base recrystallizes rapidly and produces harder suppository units with high mechanical resistance
Main formulation technologies
Suppository molding
Associated content
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