All publications
In vivo confirmation of the permeation enhancement capacity of Labrafac™ MC60
AAPS PharmSci360 – Orlando (USA) - Oct 2023
Impact of Granulation Solvent on Release Performance of Dual Matrix Extended-Release Tablets of Highly Water Soluble Drugs Formulated using Compritol® 888 ATO and Methocel® as Release Retarding Agents
AAPS PharmSci360 – Boston (USA) - Oct 2022
The purpose of this study is to evaluate the impact of different granulation solvents on the performance of dual extended- release matrix tablets, formulated using a combination of Compritol® 888 ATO and Methocel® K100M, with two model APIs:
- highly water-soluble high dose (1000 mg) Metformin Hydrochloride
- freely water-soluble low dose (95 mg) Metoprolol Succinate
A Systematic Approach to Developing Lipid-Based Drug Delivery Systems with Fenofibrate as Model Drug
AAPS PharmSci360 – Boston (USA) - Oct 2022
Labrafac™ MC60 acts as an intestinal permeation enhancer in isolated rat colonic and jejunal mucosae in the Ussing chambers
CRS Annual Meeting – Montreal (Canada) - Jul 2022
Gelucire® 48/16: a safe wetting agent for tablet. A case study with fenofibrate
CRS Annual Meeting – Montreal (Canada) - Jul 2022
Importance of standardizing protocols for pig skin preparation to ensure reliable in vitro permeation test (IVPT) results
CRS Annual Meeting – Montreal (Canada) - Jul 2022
Effect of Select Enhancers on the Permeation of Caffeine Across Strat® M Membrane
CRS Annual Meeting – Montreal (Canada) - Jul 2022
Exploring the Potential of Compritol® 888 ATO for Abuse Deterrent Sustained Release Tablets
CRS Annual Meeting – Montreal (Canada) - Jul 2022
Critical Criteria for Assessing the Permeation Performance of Topical Formulas on Animal Skin: Standardization of IVPT Protocols
PBP World Meeting – Rotterdam (The Netherlands) - Mar 2022
To assess the performance of dermal/transdermal formulation, in vitro permeation test (IVPT) with Franz cells is a reliable, reproducible, and widely used technique1. Due to its histological similarity, pig skin is a common model used as an alternative to human skin2. However, careful consideration should be given to the pig skin preparation, as both permeability and lag time can be greatly affected. The main variation sources are pig skin storage time, skin integrity and thickness, sample quantity and methodology to apply the formulation on the membrane. This study aims to investigate the critical parameters affecting the data’s accuracy by evaluating the permeation of a lidocaine hydrochloride-based gel (LID HCl) on pig skin.