All publications
A proof-of-concept for developing oral lipidized peptide Nanostructured Lipid Carrier formulations
Journal of Drug Delivery Science and Technology, Volume 54, 101394 https://doi.org/10.1016/j.jddst.2019.101394 - Dec 2019
A proof-of-concept for developing oral lipidized peptide Nanostructured Lipid Carrier formulations
Gelucire 48/16® for Type-IV Lipid Based Formulations and Their In Vitro In Vivo Performance Evaluation
AAPS PharmSci360 – San Antonion (USA) - Nov 2019
In vitro evaluation of leuprolide-containing solid lipid-based nanosuspensions: ability to encapsulate, release, protect and permeate in the gastrointestinal tract
AAPS PharmSci360 – San Antonion (USA) - Nov 2019
In this study the authors obtained solid lipid nanoparticles using high pressure homogeneization, in which leuprolide was included as an ion pair. The nanoparticles were shown to be internalized by Caco-2 and Caco-2/HT29-MTX cell monolayers.
Synergising excipients to boost skin delivery. A case study with lidocaine hydrochloride
Skinforum 2019 Annual Meeting – Reims (France) - Sep 2019
In this study, the authors showed that combining an efficient solubilizer and penetration enhancer achieves a synergic effect which enhances the passive diffusion of LID HCl through the Strat-M membrane in this Franz cell model.
Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies
Journal of Controlled Release, Volume 310, Pages 115-126 https://doi.org/10.1016/j.jconrel.2019.08.008 - Sep 2019
In this study Labrasol® ALFwas investigated as an intestinal permeation enhancer in isolated rat colonic mucosae in Ussing chamber and in rat in situ intestinal instillations.
Labrasol® ALF (4 and 8 mg/mL) enhanced the transport of the paracellular markers across colonic mucosae. The enhancement was non-damaging, transient, and molecular weight-dependent.
A snapshot of lipid excipients for topical formulations
Pharma Times – Vol. 51 – No. 59 - Sep 2019
Lipid excipients in pharmaceutical technologies
Nabil FARAH and Joel DENIS
Lipidic excipients in drug delivery for solubility and bioavailability enhancement
Prashantkumar K. PARMAR, Srilaxmi G. RAO, Arvind KK. BANSAL
From exploration of lipids to its exploitation in market: Pharmaceuticals, Nutraceuticals and Herbal
Saurabh ARORA, Abhinav GARG, Karishma KAPOOR
A snapshot of lipid excipients for topical formulations
Renuka TIWARI, Ketkee DESHMUKH, Agnivesh SHRIVASTAVA, Kanchan KOHLI
Strategic lipid-based delivery interventions for enhancing oral bioavailability of BCS II/IV drugs
Teenu SHARMA, Ranjot KAUR, Sumant SAINI, Atul JAIN, Bhupinder SINGH
Unleashing role of excipients in overcoming formulation challenges
Meenakshi VENKATARAMAN, Megha MARWAH, Mangal NAGARSENKER
Role of lipid excipients in oral sustained release drug delivery systems
Divya JAIN, Namita DESAI
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
European Journal of Pharmaceutical Sciences, Volume 137, 104967, ISSN 0928-0987, https://doi.org/10.1016/j.ejps.2019.104967. - Sep 2019
In this excellent review article issued from the UNGAP program (European Network on Understanding Gastro-intestinal Absorption-related Process) you will find relevant and up-to-date information on:
Poorly water soluble drugs and the link between physico-chemical properties and solubility, lipophilicity and permeability
Technologies to increase solubility and dissolution rate: salt formation, amorphous solid dispersions, lipid-based formulations
How to avoid precipitation and create a concentration gradient to improve absorption
Methods for modelling the performance such as Molecular Dynamics Simulations
In vitro methods for solubility and dissolution assessments
Methods to explore the absorption in the GI tract: GI concentration-time profile, in vitro digestion, in vitro models coupling dissolution and permeation, mucus diffusion
Impact of molecularly dissolved drug versus apparently dissolved drug (ie in colloidal structure)
Synergising excipients to boost skin delivery
ONdrugDelivery Magazine, Issue 99, pp 54-58. - Aug 2019
This article focuses on Transcutol® P, Capryol® and Lauroglycol™ as their synergism brings eye-opening benefits in topical formulations.
In Vitro Studies Indicate Promising Properties Of Solid Lipid Nanosuspensions for oral peptide delivery
CRS Annual Meeting – Valencia (Spain) - Jul 2019