A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.
Names & synonyms
| USP NF Name | Polyglyceryl-3 dioleate |
|---|---|
| EP Name | / |
| UNII Code (FDA) | D08AL46IU2 |
| Preferred Substance Name (FDA) | Polyglyceryl-3 dioleate |
| Handbook of Pharmaceutical Excipients | / |
| Chemical description | Consists of polyglyceryl-3 esters of oelic acid (C18:1), the diester fraction being predominant. |
Key characteristics
| Product form | Oily liquid |
|---|---|
| Viscosity (mPa.s) | 3000 (20°C) |
| HLB | 3 |
Main functionalities
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Co-surfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations.
Solubilizer and Solubilizer and skin penetration enhancer. Co-surfactant for microemulsion in topical formulations.
Safety of use is inferred by precedence of use in approved pharmaceutical products.
Main formulation technologies
Self-emulsifying lipid formulation for oral applications. Topical emulgel, microemulsion, and foam.
Resources
Technical documentation
Brochures
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Gattefosse brochure Selecting the best excipients to optimize drug delivery
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Gattefosse brochure Lipid excipients for cannabinoid drug products
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Gattefosse brochure Oral drug delivery with lipid excipients
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Gattefosse Brochure Skin-Friendly Textures
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Brochure Gattefosse Lipid-based formulations Bio-enhancers by nature
Associated content
Excipients for solubility and bioavailability enhancement
Poor solubility, poor permeability, and pre-systemic elimination are factors that…
Selecting penetration enhancers, for transdermal delivery
To overcome the skin barrier properties, many strategies exist, among which the use…