A high-purity solvent and powerful solubilizer associated with skin penetration enhancement in topical dosage forms.
Names & synonyms
| USP NF Name | Diethylene glycol monoethyl ether |
|---|---|
| EP Name | Diethylene glycol monoethyl ether |
| UNII Code (FDA) | A1A1I8X02B |
| Preferred Substance Name (FDA) | DIETHYLENE GLYCOL MONOETHYL ETHER |
| Handbook of Pharmaceutical Excipients | Diethylene glycol monoethyl ether |
| Chemical description | Consists of highly purified diethylene glycol monoethyl ether |
Key characteristics
| Product form | Liquid |
|---|---|
| Viscosity (mPa.s) | 4.8 (20°C) |
| HLB | Not applicable |
Main functionalities
Solvent and powerful solubilizer. Penetration enhancer for topical formulations. Safety of use and low irritancy inferred by numerous toxicological studies and precedence of use in approved topical medicines.
Main formulation technologies
Topical gel, emulgel, emulsion, foam, microemulsion, and ointment.
Resources
Technical documentation
Brochures
Scientific document
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Poster PBP 2024 - Formulating pharmaceutical topical dosage forms with high level of solvents and minimal quantity of water
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Poster CRS 2024 - Rheology as a tool for characterizing topical product formulations: impact of solubilizer variation on stability and structure
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Poster AAPS 2018_A systematic approach to formulate and evaluate the stability of topical creams with high concentrations of Transcutol® HP
Associated content
Selecting penetration enhancers, for transdermal delivery
To overcome the skin barrier properties, many strategies exist, among which the use…