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Construction of spheroids from melanocytes of different ethnic origins: screening model and variation
53rd Annual ESDR Meeting (4-7 September 2024, Lisbon, Portugal) - Sep 2024
Melanogenesis is a complex porcess, ans its in vitro modeling remains a challenge to develop relevant test suitable for rapid preclinical evaluation of the efficacy of lightening products to modulate human skin pigmentation.
Melanocytes are known to lose their ability to synthesize melanin in monolayer culture, even though the melanin content correlates with the ethnic background of the donors. Tissue engineering is an alternative to 2D culture because the cell behaviors in 3D microenvironment are closer to skin physiology.
We therefore compared the efficacy of 3 assays as high-throughput in vitro systems for skin-lightening drug screening: (i) Monolayer 2D culture of proliferative melanocytes, (ii) Microtissue 3D spheroid of non-proliferative melanocytes, (iii) Epidermal tissue 3D model containing functional melanocytes.
Generation of homogeneous, scaffold-free adipose spheroids for screening of lipolytic agents
ESDR - 2021
Adipose spheroids provide an interesting in vitro model of pre-adipocyte maturation and adipocyte expansion.
Fibroblasts extracellular vesicles modulate human keratinocytes differentiation during skin aging
ESDR - 2021
Microvesicles and exosomes, once considered as mechanisms of waste elimination, are now emerging as key players in intercellular communications.
A rapid and sensitive method for characterization and quantification of polyglycerol esters by supercritical fluid chromatography coupled to high-resolution mass spectrometry (SFC-HRMS)
The International Journal of Pure and Applied Analytical Chemistry - 2021
Polyglycerol esters of fatty acids are widely used in cosmetics. However, no study related to the purification and the absolute quantification of these compounds has been described yet.
The use of NADES to support innovation in the cosmetic industry
Advances in Botanical Research - 2021
Since their introduction, natural deep eutectic solvents (NaDES) have emerged as a promising, eco-friendly alternative to petrochemicals to dissolve plant metabolites.
Differential profile of proinflammatory/proresolving lipid mediators in acute inflammation model using young and old skin biopsies
Dermatology Research - 2021
Skin aging may involve an endogenous inflammation resolution program displaying dysregulation and/or absence of proresolving mediators.
An efficient method to determine the Hydrophile-Lipophile Balance of surfactants using the phase inversion temperature deviation of CiEj/n-octane/water emulsions
International Journal of Cosmetic Science - 2019
A fast and accurate method has been developed to determine the hydrophilic-lipophilic balance (HLB) number of amphiphilic chemicals.
The Camera Never Lies: Visualizing Sun Protection Loss and Ways to Fortify Films
Cosmetics&Toiletries - 2019
Visualizing sun protection loss and ways to fortify films.
Structural and biomechanical properties of a novel 3d microdermis model: the spheroid
ESDR - 2019
Spheroids as micro-tissues are a powerful alternative to standard 2D cell culture for in vitro studies.