Nos publications
Self-emulsifying drug delivery systems (SEDDS): In vivo-proof of concept for oral delivery of insulin glargine
International Journal of Pharmaceutics 639 - 122964 - mai 2023
In this study, lipophilicity of insulin glargine (IG) was successfully increased via hydrophobic ion pairing (HIP) with sodium octadecyl sulfate to enable incorporation into self-emulsifying drug delivery systems (SEDDS). The SEDDS formulations F1 and F2 were administered to rats via oral gavage and resulted in a bioavailability of 0.55% and 0.44%, corresponding to a 7.7-fold and 6.2-fold increased bioavailability, respectively. Thus, incorporation of complexed insulin glargine into SEDDS formulations provides a promising approach to facilitate its oral absorption.
LIPID-BASED EXCIPIENTS – Misconceptions About Lipid-Based Drug Delivery
Drug Development & Delivery - avr 2023
An All-Purpose Vehicle for Low-Energy Capsule Filling
Tablets&Capsules - avr 2023
Capsules are perceived as elegant, easy-to-swallow dosage forms, widely used for delivery of nutraceutical and medicinal preparations. Advances in capsule technologies have hugely facilitated the incorporation of liquid, semi-solid, and solid ingredients into capsules.
A Systematic Approach to Developing Lipid-Based Drug Delivery Systems with Fenofibrate as Model Drug
AAPS PharmSci360 – Boston (USA) - oct 2022
Impact of Granulation Solvent on Release Performance of Dual Matrix Extended-Release Tablets of Highly Water Soluble Drugs Formulated using Compritol® 888 ATO and Methocel® as Release Retarding Agents
AAPS PharmSci360 – Boston (USA) - oct 2022
The purpose of this study is to evaluate the impact of different granulation solvents on the performance of dual extended- release matrix tablets, formulated using a combination of Compritol® 888 ATO and Methocel® K100M, with two model APIs:
- highly water-soluble high dose (1000 mg) Metformin Hydrochloride
- freely water-soluble low dose (95 mg) Metoprolol Succinate
Formulation et fabrication des suppositoires [Formulation and manufacturing of suppositories].
Techniques de l’Ingénieur - oct 2022
Formulation et fabrication des suppositoires [Formulation and manufacturing of suppositories].
Techniques de l’Ingénieur - oct 2022
Effect of Lipid Vehicles on Solubility, Stability, and Topical Permeation of Delta 9 Tetrahydrocannabinol
AAPS PharmSciTech, 23:223 - jui 2022
Effect of Select Enhancers on the Permeation of Caffeine Across Strat® M Membrane
CRS Annual Meeting – Montreal (Canada) - jui 2022