Nos publications

Taste-masked drugs for pediatric medicines through lipid coating

  • Poster

AAPS Annual Meeting & Exposition – San Diego (USA)  - nov 2017

Rosiaux Y., Forest A., Girard J.M., Deleglise C., Marchaud D.

Macrogol esters: Influence on in vitro and in vivo dissolution of a poorly soluble drug

  • Poster

AAPS Annual Meeting & Exposition – San Diego (USA)  - nov 2017

Chhanda Kapadia, Meenakshi Venkataraman, Megha Marwah , Nabil J Farah , M.S. Nagarsenker

Gelucire 48/16®: A Non-Ionic Solid Surfactant for Solubility Enhancement of Poorly Soluble Drugs

  • Poster

AAPS Annual Meeting & Exposition – San Diego (USA)  - nov 2017

Chhanda Kapadia, Agnivesh Shrivastava, Sharda Gurram

Compritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets

  • Poster

AAPS Annual Meeting & Exposition – Denver (USA) - nov 2017

C. J. Kapadia, A. R. Shrivastava, G. R. Khanvilkar

LIPID-BASED DELIVERY – Are Lipid-Based Drug Delivery Systems in Your Formulation Toolbox?

  • Whitepaper

Drug Development & Delivery, Vol. 17, No. 7, p.20-25 - oct 2017

Dr. Jason LePree

This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.

Efficient taste masking through high shear coating

  • Poster

9th Conference of the European Paediatric Formulation Initiative  - 2017

Rosiaux Y., Forest A., Girard J.M., Deleglise C., Marchaud D.

Attractive emollient foams for pain treatments

  • Poster

Skinforum Annual Meeting  - jui 2017

E Dauphin-Chanard, C André and D Marchaud

Amélioration de la biodisponibilité des substances actives via la formulation [Bioavailability enhancement of active pharmaceutical ingredients through formulation strategies] galénique

  • Whitepaper

STP Pharma Pratiques, Mai-Juin 2017, n°1 - 2017

E Levacher, C Buffangeix, MJ Celadon, I Decorte, P Gestin, J Hecq, F Jego, B Paillard, A Plantefeve, X Thomas

The SFSTP commission on Bioavailability published an article reviewing the formulation strategies to enhance the bioavailability of APIs.

Interestingly this article is both in French and English languages.

Table of content:

I Introduction

II Prerequisites

1 Initial identification and characterization of the active ingredient
1.1 Physico-chemical characteristics
1.2 Impact of physicochemical characteristics on absorption
1.3 Passive diffusion prediction tools
1.4 In silico prediction
2 Biopharmaceutical classifications

III Formulation strategies

1 Prerequisites
2 Techniques for increasing the dissolution rate
3 Solubility enhancement technologies
4 Improving the permeability, oral route

IV Control, assessment, prediction of the bioavailability

1 Physicochemical control methods for the manufacturing intermediates and finished products
2 Assessing and predicting the bioavailability of the formulations

V Alternative strategy: changing the route of administration

VI Conclusion: decision tree

Inclusion of digestible surfactants in solid SMEDDS formulation removes lag time and influences the formation of structured particles during digestion

  • Scientific publication

The AAPS Journal, Vol. 19, No. 3 - mai 2017

Kapilkumar Vithani, Adrian Hawley, Vincent Jannin, Colin Pouton, Ben J. Boyd

The objective of this study is to evaluate how solid self-microemulsifying drug delivery systems (SMEDDS) behave during digestion. SMEDDS containing Gelucire® 44/14 and surfactants were prepared and their dispersion and digestion behaviors were studied using an in vitro lipolysis model, coupled with small-angle X-ray scattering (SAXS) to determine the formed colloidal structures during digestion in real time.

The study shows that the lipid to surfactant ratio has a significant effect on the kinetics of digestion and an optimum ratio is prerequisite to develop rapidly digestible solid SMEDDS system.