Nos publications
Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione
International Journal of Pharmaceutics, Volume 523, Issue 1, Pages 357–365 https://doi.org/10.1016/j.ijpharm.2017.03.027 - mai 2017
This study shows that independent from the type of peptide all the SEDDS showed a prolonged release and can provide a 100% protective effect towards protease degradation and deactivation by reduced glutathione.
Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery systems
International Journal of Pharmaceutics, Volume 520, Issues 1–2, 30 March 2017, Pages 267–274 - mar 2017
In this study, hydrophobic ion pairing is used to form complexes between different anionic surfactants and leuprorelin, insulin and desmopression as model peptides. These complexes were formulated in SEDDS and evaluated for payload and stability.
Comparative evaluation of Compritol® HD5 ATO with Sodium Stearyl Fumarate and PEG 6000 as amphiphilic, hydrodispersible pharmaceutical lubricants
Journal of Excipients and Food Chemicals, Vol. 8, Issue 1, pages 5-17 - mar 2017
In the present study the lubricant capacity of Compritol® HD5 ATO was compared with commonly used amphiphilic lubricants. The
effect of the concentration and mixing time on flow properties, tablet ejection force, hardness, disintegration time and rate of dissolution of paracetamol tablets was evaluated.
The physical properties of the lubricants such as crystallinity, wettability, thermal behaviour and surface area were also measured.
Compritol® HD5 ATO was found to be an as effective a lubricant for a fast disintegrating paracetamol formulation containing microcrystalline cellulose, lactose and PVP prepared by wet granulation in comparison with sodium stearyl fumarate and PEG 6000.
In-vitro investigation regarding the effects of Gelucire® 44/14 and Labrasol® ALF on the secretory intestinal transport of P-gp substrates
International Journal of Pharmaceutics, Volume 515, Issues 1–2, Pages 293-299 https://doi.org/10.1016/j.ijpharm.2016.10.012 - déc 2016
Solidification of liquid self-emulsifying lipid formulations by loading on solid mesoporous carriers
PBP World Meeting 2016 – Glasgow (Scotland) - nov 2016
Gelucire® 48/16: a solid surfactant for tablets
Pharma Times, Vol. 48 – N° 11 – pp 17-22 - nov 2016
This article describes Gelucire® 48/16 – a novel pegylated lipid excipient, and its use as a solid surfactant for solubility enhancement.
Solid State Structural Aspects of Solid Self-microemulsifying Drug Delivery Systems (sSMEDDS) during Digestion
AAPS Annual Meeting & Exposition – Denver (USA) - nov 2016
Compritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets
AAPS Annual Meeting & Exposition – Denver (USA) - nov 2016
Converting simple microemulsion into attractive foam for topical pain treatment. A case study with lidocaine base
AAPS Annual Meeting & Exposition – Denver (USA) - nov 2016