Nos publications
Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs
Advanced Drug Delivery Reviews, Volume 142, Pages 16-34 https://doi.org/10.1016/j.addr.2019.01.008 - mai 2019
In this review article, the authors explain the importance of the colloidal structures formed during dispersion and digestion of self emulsifying lipid-based formulations on drug solubilization and absorption.
A review of the techniques used to characterize the colloidal structures is also carried out.
An efficient method to determine the Hydrophile-Lipophile Balance of surfactants using the phase inversion temperature deviation of Ci Ej /n-octane/water emulsions.
International Journal of Cosmetic Science, 41, 99–108 doi: 10.1111/ics.12516 - avr 2019
Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis
International Journal of Pharmaceutics, Volume 559, Pages 228-234 - mar 2019
Lipids and polymers in pharmaceutical technology: Lifelong companions
International Journal of Pharmaceutics, Volume 558, 10 March 2019, Pages 128-142 - mar 2019
This article reviews the uses of lipids and polymers in pharmaceutical applications, alone or in combination, with a main focus on oral administration.
These topics were discussed at the Journées galéniques de Saint-Rémy de Provence in 2018, the Scientific Meeting sponsored by Gattefossé Foundation
High shear blending with glyceryl distearate provides individually coated drug particles for effective taste masking
Journal of Drug Delivery Science and Technology, Volume 48, Pages 437-449 - déc 2018
In this study the authors used:
– A design of experiment, to evaluate the effect of process parameters (blending speed, chopper speed and coating time) on drug particle size.
– Potassium chloride as model drug.
The study showed:
– Individual particle coating was achieved at 450 rpm with 20% glyceryl distearate (Precirol® ATO 5) at 48°C
– High shear coating is as efficient as fluid bed coating for taste masking
– A trained sensory panel confirmed the effectiveness of the process on taste masking
TAM Technique for Identifying API-Lipid Excipient Compatibility Issues Upstream in the Development Process
AAPS PharmSci 360 – Washington DC (USA) - nov 2018
In this study the authors showed that Thermal Activity Monitoring is a useful technique to detect at early stage potential interaction between APi and excipients, using less time and resources than conventional techniques.
TAM technique is used routinely in Gattefossé North America Technical Center of Excellence to speed up formulation development.
Gelucire 48/16®: A Versatile Non-Ionic Solid Solubilizer for Tablets of Poorly Water-Soluble Drugs
AAPS PharmSci360 – Washington DC (USA) - nov 2018
A solid dispersion of ticagrelor and Gelucire® 48/16 is prepared to increase drug solubility . The solid dispersion is converted into tablets. The formulated tablets showed improved dissolution rate compared to the market reference.
A systematic approach to formulate and evaluate the stability of topical creams with high concentrations of Transcutol® HP
AAPS PharmSci 360 – Washington DC (USA) - nov 2018
In this study the authors developped stable anhydrous and hydrous creams containing 40% Transcutol® HP, using predictive techniques to select appropriate excipients.
Skin Penetration and Permeation Properties of Transcutol®—Neat or Diluted Mixtures
AAPS PharmSciTech, Vol. 19, No.8 DOI: 10.1208/s12249-018-1196-8 - nov 2018
In this critical article, the authors have reviewed numerous studies in order to elucidate the mechanism of action of the highly purified diethylene glycol monoethyl ether TRANSCUTOL® on skin penetration and permeation.