Nos publications
Taste-masked drugs for pediatric medicines through lipid coating
AAPS Annual Meeting & Exposition – San Diego (USA) - nov 2017
Macrogol esters: Influence on in vitro and in vivo dissolution of a poorly soluble drug
AAPS Annual Meeting & Exposition – San Diego (USA) - nov 2017
Gelucire 48/16®: A Non-Ionic Solid Surfactant for Solubility Enhancement of Poorly Soluble Drugs
AAPS Annual Meeting & Exposition – San Diego (USA) - nov 2017
Compritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets
AAPS Annual Meeting & Exposition – Denver (USA) - nov 2017
LIPID-BASED DELIVERY – Are Lipid-Based Drug Delivery Systems in Your Formulation Toolbox?
Drug Development & Delivery, Vol. 17, No. 7, p.20-25 - oct 2017
This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.
Efficient taste masking through high shear coating
9th Conference of the European Paediatric Formulation Initiative - 2017
Attractive emollient foams for pain treatments
Skinforum Annual Meeting - jui 2017
Amélioration de la biodisponibilité des substances actives via la formulation [Bioavailability enhancement of active pharmaceutical ingredients through formulation strategies] galénique
STP Pharma Pratiques, Mai-Juin 2017, n°1 - 2017
The SFSTP commission on Bioavailability published an article reviewing the formulation strategies to enhance the bioavailability of APIs.
Interestingly this article is both in French and English languages.
Table of content:
I Introduction
II Prerequisites
1 Initial identification and characterization of the active ingredient
1.1 Physico-chemical characteristics
1.2 Impact of physicochemical characteristics on absorption
1.3 Passive diffusion prediction tools
1.4 In silico prediction
2 Biopharmaceutical classifications
III Formulation strategies
1 Prerequisites
2 Techniques for increasing the dissolution rate
3 Solubility enhancement technologies
4 Improving the permeability, oral route
IV Control, assessment, prediction of the bioavailability
1 Physicochemical control methods for the manufacturing intermediates and finished products
2 Assessing and predicting the bioavailability of the formulations
V Alternative strategy: changing the route of administration
VI Conclusion: decision tree

Inclusion of digestible surfactants in solid SMEDDS formulation removes lag time and influences the formation of structured particles during digestion
The AAPS Journal, Vol. 19, No. 3 - mai 2017
The objective of this study is to evaluate how solid self-microemulsifying drug delivery systems (SMEDDS) behave during digestion. SMEDDS containing Gelucire® 44/14 and surfactants were prepared and their dispersion and digestion behaviors were studied using an in vitro lipolysis model, coupled with small-angle X-ray scattering (SAXS) to determine the formed colloidal structures during digestion in real time.
The study shows that the lipid to surfactant ratio has a significant effect on the kinetics of digestion and an optimum ratio is prerequisite to develop rapidly digestible solid SMEDDS system.