Nos publications

A snapshot of lipid excipients for topical formulations

  • Whitepaper

Pharma Times – Vol. 51 – No. 59 - sep 2019

Gattefossé

Lipid excipients in pharmaceutical technologies
Nabil FARAH and Joel DENIS

Lipidic excipients in drug delivery for solubility and bioavailability enhancement
Prashantkumar K. PARMAR, Srilaxmi G. RAO, Arvind KK. BANSAL

From exploration of lipids to its exploitation in market: Pharmaceuticals, Nutraceuticals and Herbal
Saurabh ARORA, Abhinav GARG, Karishma KAPOOR

A snapshot of lipid excipients for topical formulations
Renuka TIWARI, Ketkee DESHMUKH, Agnivesh SHRIVASTAVA, Kanchan KOHLI

Strategic lipid-based delivery interventions for enhancing oral bioavailability of BCS II/IV drugs
Teenu SHARMA, Ranjot KAUR, Sumant SAINI, Atul JAIN, Bhupinder SINGH

 Unleashing role of excipients in overcoming formulation challenges
Meenakshi VENKATARAMAN, Megha MARWAH, Mangal NAGARSENKER

Role of lipid excipients in oral sustained release drug delivery systems
Divya JAIN, Namita DESAI

Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

  • Scientific publication

European Journal of Pharmaceutical Sciences, Volume 137, 104967, ISSN 0928-0987, https://doi.org/10.1016/j.ejps.2019.104967. - sep 2019

Ben J. Boyd, Christel A.S. Bergström, Zahari Vinarov, Martin Kuentz, Joachim Brouwers, Patrick Augustijns, Martin Brandl, Andreas Bernkop-Schnürch, Neha Shrestha, Véronique Préat, Anette Müllertz, Annette Bauer-Brandl, Vincent Jannin

In this excellent review article issued from the UNGAP program (European Network on Understanding Gastro-intestinal Absorption-related Process) you will find relevant and up-to-date information on:


Poorly water soluble drugs and the link between physico-chemical properties and solubility, lipophilicity and permeability
Technologies to increase solubility and dissolution rate: salt formation, amorphous solid dispersions, lipid-based formulations
How to avoid precipitation and create a concentration gradient to improve absorption
Methods for modelling the performance such as Molecular Dynamics Simulations
In vitro methods for solubility and dissolution assessments
Methods to explore the absorption in the GI tract: GI concentration-time profile, in vitro digestion, in vitro models coupling dissolution and permeation, mucus diffusion
Impact of molecularly dissolved drug versus apparently dissolved drug (ie in colloidal structure)

Synergising excipients to boost skin delivery

  • Whitepaper

ONdrugDelivery Magazine, Issue 99, pp 54-58. - aou 2019

C. Morin and D. Marchaud

This article focuses on Transcutol® P, Capryol® and Lauroglycol™ as their synergism brings eye-opening benefits in topical formulations.

In Vitro Studies Indicate Promising Properties Of Solid Lipid Nanosuspensions for oral peptide delivery

  • Poster

CRS Annual Meeting – Valencia (Spain)  - jui 2019

Camille Dumont, Ana Beloqui, Sandrine Bourgeois, Véronique Préat, Hatem Fessi, Vincent Jannin

Understanding The Role Of In Vitro And In Vivo Evaluation Techniques In Determining the Performance of Lipid-Based Formulations

  • Poster

CRS Annual Meeting – Valencia (Spain)  - jui 2019

Ketkee DESHMUKH, Agnivesh SHRIVASTAVA, Sunil BAMBARKAR, Nabil FARAH, Kavita SINGH

In this case study using curcuminoids as model drug, the authors show that in vitro lipolysis test is a useful tool to predict in vivo performance 

Investigation of the permeation enhancer strategy on benzoylaconitine transdermal patch: the relationship between transdermal enhancement strength and physicochemical properties of permeation enhancer

  • Scientific publication

Eur J Pharm Sci. 2019 Oct 1;138:105009. doi: 10.1016/j.ejps.2019.105009. Epub 2019 Jul 12. - jui 2019

Liu C, Farah N, Weng W, Jiao B, Shen M, Fang L

In this study several permeation enhancers are evaluated for their ability to permeate high molecular weight benzoylaconitine. The results showed that Plurol® Oleique CC 497 enabled the highest permeation. FT-IR studies demonstrated that the enhancer had strong interactions with the Stratum corneum, both in the hydrophilic and lipophilic regions. The optimized patch formulation showed excellent analgesic and antiinflammatory effect.

In-vitro evaluation of solid lipid nanoparticles: Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract

  • Scientific publication

International Journal of Pharmaceutics, Volume 565, Pages 409-418 - jui 2019

Camille Dumont, Sandrine Bourgeois, Hatem Fessib, Pierre-Yves Dugas, Vincent Jannin

Investigation of Labrasol® ALF as an intestinal permeation enhancer: Ussing chambers and intestinal instillations

  • Poster

Poster presented at Keystone Symposia on Molecular and Cellular Biology – Delivering Therapeutics Across Biological Barriers (E1) - Dublin (Ireland)  - mai 2019

Fiona McCartney, Vincent Jannin and David J. Brayden

A Proof of Concept for 3D Printing of Solid Lipid-Based Formulations of Poorly Water-Soluble Drugs to Control Formulation Dispersion Kinetics

  • Scientific publication

Pharmaceutical Research volume 36, Article number: 102 doi: 10.1007/s11095-019-2639-y. - mai 2019

Vithani K, Goyanes A, Jannin V, Basit AW, Gaisford S, Boyd BJ

In this study, the authors show that solid SMEDDS can be produced with a 3D printing  process and solid and semi-solid lipid excipients. The proof of concept is established with cinnarizine and fenofibrate as model drugs.